Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London

Michelle A. Miller; Sally M. Kerry; Yanbin Dong; Pasquale Strazzullo; Francesco P. Cappuccio

doi:10.1160/TH04-04-0228

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(05): 1060-1065
DOI: 10.1160/TH04-04-0228

Wound Healing and Inflammation/Infection

Schattauer GmbH

Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London

Michelle A. Miller

¹Department of Community Health Sciences, St George’s Hospital Medical School, London UK

,

Sally M. Kerry

¹Department of Community Health Sciences, St George’s Hospital Medical School, London UK

,

Yanbin Dong

²Georgia Prevention Institute, Medical College of Georgia, Augusta, Georgia, USA

,

Pasquale Strazzullo

³Department of Clinical & Experimental Medicine, Federico II University, Naples, Italy

,

Francesco P. Cappuccio

¹Department of Community Health Sciences, St George’s Hospital Medical School, London UK

› Author Affiliations

Abstract

Summary

The aim was to investigate whether the Thr715Pro P-selectin polymorphism is associated with soluble P-selectin (sP-selectin) levels in individuals from different ethnic groups. Plasma sPselectin and Thr715Pro (A/C) P-selectin gene polymorphism were measured in 237 white (106 females), 177 black African origin (92 females) and 201 South Asian (94 females) individuals living in England. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. The Thr715Pro C allele was rare in blacks (0.8%) and intermediate in South Asians (3.0%) compared to whites (11.2%; p <0.001). sP-selectin levels were significantly lower in the individuals with the AC or CC compared to the AA genotype in both whites (-25% (95% C.I. -33.3 to -16.9); p <0.001) and South Asians (-25.2% (-40.5 to -6.1); p <0.012). There was insufficient power for this analysis in blacks. In conclusion, in whites and South Asians the C allele of the Thr715Pro P-selectin polymorphism is associated with lower sP-selectin levels. Lower levels of sP-selectin were not accounted for by this polymorphism in blacks, in whom the C allele was very rare.

Keywords

Ethnicity - polymorphism - sP-selectin - inflammation - cardiovascular disease

Full Text

References

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