Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII

Sam Schulman; Geir E. Tjønnfjord; Richard Wallensten; Uri Martinowitz; Gili Kenet

doi:10.1160/TH05-05-0342

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 94(06): 1177-1180
DOI: 10.1160/TH05-05-0342

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII

Sam Schulman

¹Coagulation Unit, Department of Haematology and

,

Geir E. Tjønnfjord

³Section of Haematology, Department of Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway

,

Richard Wallensten

²Department of Orthopaedic Surgery, Karolinska University Hospital, Stockholm, Sweden

,

Uri Martinowitz

⁴The National Hemophilia Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel

,

Gili Kenet

⁴The National Hemophilia Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel

› Institutsangaben

Abstract

Summary

The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factorVII (FVII) deficiency. The results of 12 consecutive surgical procedures in 7 patients with congenital FVII deficiency are reported here. rFVIIa was always given in continuous infusion, aiming at plasma FVII activity of 0.5 IU/mL. Treatment was given for 2 to 7 days with a mean total dose of 7.8 mg rFVIIa. Blood loss was as expected from the different types of procedures and the only thromboembolic complication was a superficial thrombophlebitis at the infusion site. This mode of substitution was therefore safe, effective and well tolerated.

Keywords

Factor VII deficiency - recombinant factor VIIa - surgery - bleeding

Volltext

Referenzen

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