Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis

Erhard Hofer; Bernhard Schweighofer

doi:10.1160/TH06-08-0470

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2007; 97(03): 355-363
DOI: 10.1160/TH06-08-0470

Theme Issue Article

Schattauer GmbH

Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis

Erhard Hofer

¹Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna. Austria

,

Bernhard Schweighofer

¹Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna. Austria

› Institutsangaben

Abstract

Summary

New vessel formation during development and in the adult is triggered by concerted signals of largely endothelial-specific receptors for ligands of the VEGF, angiopoietin and ephrin families. The signals and genes induced by these receptors operate in the context of additional signals transduced by non-endothelial specific growth factor receptors, inflammatory cytokine receptors as well as adhesion molecules. We summarize here available data on characteristic signaling of the VEGF receptor-2 and the current state of knowledge regarding the additional different receptor tyrosine kinases of the VEGF, Tie and Ephrin receptor families. Furthermore, the potential cross-talk with signals induced by other growth factors and inflammatory cytokines as well as the modulation by VE-cadherin is discussed.

Keywords

Angiogenesis and inhibitors - signal transduction - endothelial cells

Volltext

Referenzen

References
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