Distribution of von Willebrand factor levels in young women with and without bleeding symptoms. Influence of ABO blood group and promoter haplotypes

Stefan Lethagen; Andreas Hillarp; Caroline Ekholm; Eva Mattson; Christer Halldén; Britt Friberg

doi:10.1160/TH07-06-0419

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2008; 99(06): 1013-1018
DOI: 10.1160/TH07-06-0419

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Distribution of von Willebrand factor levels in young women with and without bleeding symptoms. Influence of ABO blood group and promoter haplotypes

Stefan Lethagen

¹Department for Coagulation Disorders, Malmö University Hospital, Sweden

²Center for Hemostasis and Thrombosis, Copenhagen University Hospital (Rigshospitalet), Denmark

,

Andreas Hillarp

³Department of Clinical Chemistry, Malmö University Hospital, Malmö, Sweden

,

Caroline Ekholm

²Center for Hemostasis and Thrombosis, Copenhagen University Hospital (Rigshospitalet), Denmark

,

Eva Mattson

²Center for Hemostasis and Thrombosis, Copenhagen University Hospital (Rigshospitalet), Denmark

,

Christer Halldén

³Department of Clinical Chemistry, Malmö University Hospital, Malmö, Sweden

,

Britt Friberg

⁴Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden

› Institutsangaben

Abstract

Summary

The normal distribution of von Willebrand factor (VWF) levels is wide. Low levels are associated with bleeding symptoms and von Willebrand disease (VWD). We have recently described a high prevalence of bleeding symptoms in a whole age group of young females (n = 1,019) from Malmo, Sweden. It was the objective of the present study to evaluate the distribution of VWF levels in young females with or without bleeding symptoms in this population, and the influence of ABO blood group and promoter haplotypes on VWF levels and to identify a possible increased prevalence of VWD in females with bleeding symptoms. A random selection of the female age group (n = 246), into a study group (n = 176) with, and a control group (n = 70) without bleeding symptoms, was evaluated. Eighteen girls had VWF:RCo below the reference range, of which 17 belonged to the study group (17/176, 9.7%), and one to the control group (1/70, 1.4%) (p = 0.017). Blood group O was found in 14/18 girls with low VWF:RCo. There was a highly significant correlation between VWF:RCo and blood group O and non-O genotypes. Two common VWF promoter haplotypes did not contribute to the VWF:RCo variation. VWF levels did not correlate with time during menstrual cycle, or the use of oral contraceptives. No case fulfilled the diagnostic criteria for VWD. In conclusion, low VWF:RCo was significantly more frequent in females with bleeding symptoms. However, we found no case fulfilling strict diagnostic criteria for VWD. The ABO blood group was a strong modifier, but VWF promoter haplotypes had no association to VWF levels in this population.

Keywords

Inherited coagulation disorders - oral contraceptives - von Willebrand - disease - clinical studies - menorrhagia

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Referenzen

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