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Thromb Haemost 2009; 102(01): 25-28
DOI: 10.1160/TH09-01-0043
Rapid and Short Communication
Schattauer GmbH

Laboratory criteria of the obstetrical antiphospholipid syndrome

Data from a multicentric prospective European women cohort
Marie-Claire Boffa
1   Laboratoire d’Hématologie, Unité Hémostase et Thrombose, AP- Hôpitaux de Paris, Hôpital Jean-Verdier, Bondy, France
,
Catherine Boinot
2   Service d’Hématologie et Oncologie Biologique, Centre Hospitalier et Université de Poitiers, Poitiers, France
,
Sara De Carolis
3   Department of Obstetrics and Gynecology, Catholic University, Rome, Italy
,
Patrizia Rovere-Querini
4   San Raffaele Scientific Institute, Milano, Italy
,
Marie-Hélène Aurousseau
1   Laboratoire d’Hématologie, Unité Hémostase et Thrombose, AP- Hôpitaux de Paris, Hôpital Jean-Verdier, Bondy, France
,
Flavio Allegri
5   Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy
,
Pascale Nicaise-Roland
1   Laboratoire d’Hématologie, Unité Hémostase et Thrombose, AP- Hôpitaux de Paris, Hôpital Jean-Verdier, Bondy, France
6   Immunologie, AP-HP Hôpital Bichat, Claude Bernard, Paris, France
,
Anne Barra
7   Laboratoire d’Immunologie, Centre Hospitalier et Université de Poitiers, Poitiers, France
,
Angela Botta
8   Department of Rheumatology and Immunology, Catholic University, Rome, Italy
,
Ales Ambrozic
9   Department of Rheumatology and Immunology, University Medical Center, Ljubljana, Slovenia
,
Tadej Avcin
10   Pediatrics, University Medical Center, Ljubljana, Slovenia
,
Angela Tincani
5   Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy
› Author Affiliations
Further Information

Publication History

Received: 19 January 2009

Accepted after minor revision: 08 April 2009

Publication Date:
24 November 2017 (online)

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Summary

A debate on updating the laboratory criteria of antiphospholipid syndrome (APS) was recently opened in view to lower the risk of over diagnosis of the syndrome. Based on data related to thrombotic APS, it proposes the exclusion of anticardiolipin antibodies (aCL) and anti-beta2-glycoprotein 1 (a-β2-GPI) IgM detection. Here, we examine this possibility in a study which focuses on obstetrical APS (OAPS).We report new data on a prospective multicenter European cohort of 109 pregnant women having APS.Among them, 73 had purely obstetrical APS, not associated to autoimmune diseases or thrombosis. Isolated antibodies and isolated aCL positivity were present in 50/109 (46%) and in 34/109 (31%) of the women, respectively. An isolated a-β2-GPI IgM was present in three women.These results suggest that aCL and a-β2-GPI IgM cannot be dropped for the diagnosis and classification of OAPS.The low level of some antibodies associated with severe obstetrical complications raise the issue of keeping or not the same laboratory criteria for OAPS and for thrombotic APS and whether additional criteria after large prospective studies could further improve diagnosis.

Keywords

Anticardiolipin antibody - anti-beta2-glycoprotein I antibody - obstetrical antiphospholipid syndrome - thrombotic antiphospholipid syndrome - antiphospholipid syndrome diagnosis
 

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