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Thromb Haemost 2011; 105(01): 122-130
DOI: 10.1160/TH10-06-0363
Platelets and Blood Cells
Schattauer GmbH

Strenuous physical exercise adversely affects monocyte chemotaxis

Frauke S. Czepluch   *
1   Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands
,
Romain Barrès   **
2   Department Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
,
Kenneth Caidahl
3   Department Molecular Medicine and Surgery, Karolinska Institutet, and Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
,
Servé Olieslagers
1   Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands
,
Anna Krook
4   Department Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
,
Anette Rickenlund
3   Department Molecular Medicine and Surgery, Karolinska Institutet, and Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
,
Anette Rickenlund
3   Department Molecular Medicine and Surgery, Karolinska Institutet, and Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
,
Juleen R. Zierath
2   Department Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
4   Department Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
,
Johannes Waltenberger   ***
1   Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands
› Author Affiliations Financial support:This work was supported by a Marie Curie Fellowship (F.S.C.), the Cardiovascular Research Institute Maastricht (J.W.), the European Foundation for the Study of Diabetes, Swedish Research Council, Swedish Diabetes Association, Strategic Research Foundation, the Swedish Heart and Lung foundation, Knut and Alice Wallenberg foundation, Novo Nordisk Research Foundation, the Stockholm County Council, the French Foundation for Medical Research and Commission of the European Communities (Contract No LSHM-CT-2004–005272 EXGENESIS).
Further Information

Publication History

Received: 10 June 2010

Accepted after major revision: 08 October 2010

Publication Date:
22 November 2017 (online)

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Summary

Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-β1 (TGF-β1) was completely inhibited immediately after training (p<0.01), and remained so after four weeks recovery. Likewise, monocyte chemoattractant protein-1 (MCP-1)-induced migration declined after training (p<0.01) and improved only partially during the recovery period. MCP-1 serum levels were significantly reduced after four weeks recovery compared to baseline (p<0.01). Total blood antioxidant capacity was enhanced at this time point (p<0.01). Monocyte chemokinesis, TGF-β1 and nitric oxide serum levels remained unchanged during the study. Strenuous three-week training consisting of repeated exercise bouts in healthy, sedentary individuals reduces monocyte chemotaxis. It remains to be established, whether this is a sound adaptation to increased stimuli or an untoward reaction to overtraining. Nevertheless, the effect remains for several weeks with no exercise.

Keywords

Exercise - monocytes - chemotaxis - VEGF-A - TGF-β1

* Present address of F.S.C. is Department of Cardiology and Pneumology, Georg-August-University, Göttingen, Germany.


** R.B. is now at the Department of Health and Exercise Science, University of New South Wales, Sydney, Australia.


*** Present address of J.W. is Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany.


 

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