Thromb Haemost 2017; 117(08): 1571-1581
DOI: 10.1160/TH16-11-0837
Cellular Haemostasis and Platelets
Schattauer GmbH

Microparticles during long-term follow-up after acute myocardial infarction

Association to atherosclerotic burden and risk of cardiovascular events
Christina Christersson
1   Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
,
Åsa Thulin
2   Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
,
Agneta Siegbahn
2   Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
› Institutsangaben

Financial support: Financial support for this study was received from the Erik, Karin and Gösta Selander Foundation, the Mats Kleberg Foundation, the Fondkistan Foundation and the Swedish Research Council, the Swedish Heart and Lung foundation and the Swedish Foundation for Strategic Research (SSF).
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Publikationsverlauf

Received: 07. November 2016

Accepted after minor revision: 05. April 2017

Publikationsdatum:
22. November 2017 (online)

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Summary

Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU). Patients with non-ST-elevated MI had higher concentrations of CD41+MPs compared to ST-elevated MI patients (p=0.024). The concentrations of PMPs in whole blood increased during the time period (p<0.001), but no significant change over time was found for EMPs and MMPs. CD62P+MP counts were higher in MI patients with diabetes (p=0.020), and patients with hypertension had increased levels of CD14+MPs (p=0.004). The amount of CD62P+TF+MPs increased significantly during FU (p<0.001). Patients with atherosclerosis in three arterial beds, i. e. coronary, carotid and peripheral arteries, had lower concentrations of CD62P+TF+MPs (p=0.035) and CD144+TF+MPs (p=0.004) compared to patients with atherosclerosis in one or two arterial beds. Higher concentrations of CD62P+MPs early after MI were associated with an increased risk of cardiovascular events during FU, hazard ratio 3.32 (95%CI1.20–9.31). Only small variations in PMP, EMP and MMP concentrations were found during long-term FU after MI and their levels seem to reflect the underlying cardiovascular disease rather than the acute MI. PMPs expressing P-selectin might be a promising biomarker for predicting future cardiovascular events, but further studies are needed to confirm these results.

Supplementary Material to this article is available online at www.thrombosis-online.com.