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Thromb Haemost 2011; 105(S 06): S75-S81
DOI: 10.1160/THS10-12-0769
Thrombosis and Haemostasis Supplement
Schattauer GmbH

Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors

Robert F. Storey
1   Department of Cardiovascular Science, University of Sheffield, Sheffield, UK
› Author Affiliations
Further Information

Publication History

Received: 02 December 2010

Accepted after minor revision: 07 January 2011

Publication Date:
06 December 2017 (online)

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Summary

The important role of the P2Y12 receptor in amplification of platelet activation and associated responses and the limitations associated with clopidogrel therapy have led to the development of novel inhibitors of this receptor. Three reversibly-binding P2Y12 inhibitors are in phase 3 development, ticagrelor, cangrelor and elinogrel. The pharmacology and clinical trial data for each of these inhibitors are discussed and compared with relevant data for the thienopyridines clopidogrel and prasugrel.

Keywords

ADP receptors - antiplatelet agents - arterial thrombosis - platelet pharmacology - antiplatelet drugs
 

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