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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(01): 35-43
DOI: 10.1590/0004-282X20150188
ARTICLE

Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

Lobectomia temporal anterior versus amigdalohipocampectomia seletiva para epilepsia de lobo temporal mesial
Fábio A. Nascimento
1   University of Toronto, Toronto Western Hospital, Division of Neurology, Toronto, Ontario, Canada;
,
Luana Antunes Maranha Gatto
2   Universidade Federal do Paraná, Hospital de Clinicas, Departamento de Neurocirurgia, Curitiba PR, Brazil;
,
Carlos Silvado
3   Universidade Federal do Paraná, Hospital de Clinicas, Departamento de Neurologia, Serviço de Epilepsia e Eletroencefalograma, Curitiba PR, Brazil;
,
Maria Joana Mäder-Joaquim
4   Universidade Federal do Paraná, Hospital de Clinicas, Departamento de Neurologia, Curitiba PR, Brazil.
,
Marlus Sidney Moro
2   Universidade Federal do Paraná, Hospital de Clinicas, Departamento de Neurocirurgia, Curitiba PR, Brazil;
,
Joao Candido Araujo
2   Universidade Federal do Paraná, Hospital de Clinicas, Departamento de Neurocirurgia, Curitiba PR, Brazil;
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ABSTRACT

ObjectiveTo contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH).

MethodThis is a retrospective observational study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications.

ResultSixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients’ dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004).

ConclusionSeizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.

RESUMO

ObjetivoContribuir com nossa experiência para o tratamento cirúrgico de pacientes com epilepsia do lobo temporal mesial submetidos a lobectomia temporal anterior (LTA) ou amigdalohipocampectomia seletiva (AHS).

MétodoEstudo retrospectivo observacional. Foram incluídos pacientes com epilepsia refratária devido a esclerose mesial temporal unilateral, submetidos a LTA ou AHS no Hospital de Clínicas – UFPR, entre 2005-2012. Foram comparados os resultados cognitivos (análises de memórias verbal e visuoespacial), controle de crises (Engel) e complicações cirúrgicas.

ResultadosSessenta e sete pacientes (33 LTA, 34 AHS) foram estudados; o período de acompanhamento médio foi de 64 meses. Não houve diferença no controle das crises ou resultado neuropsicológico, mas a memória verbal foi mais negativamente afetada nos pacientes submetidos à LTA no hemisfério dominante. Maior número de complicações graves ocorreu no grupo de LTA (p = 0.004).

ConclusãoControle de crises e resultados neuropsicológicos não diferiram. LTA pareceu estar associada a um maior risco cirúrgico.

temporal lobe epilepsy - amygdalo-hippocampal epilepsy - anterior temporal lobectomy - neuropsychological tests - seizures - postoperative complications
epilepsia do lobo temporal - epilepsia amígdalo-hipocampal - lobectomia temporal anterior - testes neuropsicológicos - crises convulsivas - complicações pós-operatórias


Publication History

Received: 25 May 2015

Accepted: 22 September 2015

Article published online:
06 September 2023

© 2015. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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