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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(05): 296-301
DOI: 10.1590/0004-282X20180036
Article

Suicidal ideation, anxiety, and depression in patients with multiple sclerosis

Ideação suicida, ansiedade e depressão em pacientes com esclerose múltipla
Carlos Bernardo Tauil
1   Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil;
2   Universidade Católica de Brasília, Brasília DF, Brasil;
5   Universidade de Brasília, Departamento de Medicina Interna, Brasília DF, Brasil.
,
Talyta Cortez Grippe
1   Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil;
5   Universidade de Brasília, Departamento de Medicina Interna, Brasília DF, Brasil.
,
Ronaldo Maciel Dias
1   Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil;
,
Rafael Paternò Castello Dias-Carneiro
3   Santa Casa de São Paulo, Disciplina de Neurologia, Centro de Atendimento e Tratamento da Esclerose Múltipla, São Paulo SP, Brazil;
,
Narel Moita Carneiro
1   Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil;
,
Ana Carolina Rodrigues Aguilar
1   Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil;
,
Flávia Martins da Silva
1   Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil;
,
Felipe Bezerra
2   Universidade Católica de Brasília, Brasília DF, Brasil;
,
Leonardo Kenzo de Almeida
2   Universidade Católica de Brasília, Brasília DF, Brasil;
,
Vitoria Lana Massarente
3   Santa Casa de São Paulo, Disciplina de Neurologia, Centro de Atendimento e Tratamento da Esclerose Múltipla, São Paulo SP, Brazil;
,
Elaine de Carvalho Giovannelli
3   Santa Casa de São Paulo, Disciplina de Neurologia, Centro de Atendimento e Tratamento da Esclerose Múltipla, São Paulo SP, Brazil;
,
Charles Peter Tilbery
3   Santa Casa de São Paulo, Disciplina de Neurologia, Centro de Atendimento e Tratamento da Esclerose Múltipla, São Paulo SP, Brazil;
,
Carlos Otávio Brandão
4   Universidade de Campinas, Departamento de Neuroimunologia, Campinas SP, Brasil;
,
Leonilda Maria B Santos
4   Universidade de Campinas, Departamento de Neuroimunologia, Campinas SP, Brasil;
,
Leopoldo dos Santos-Neto
5   Universidade de Brasília, Departamento de Medicina Interna, Brasília DF, Brasil.
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ABSTRACT

Psychiatric disorders frequently occur in patients with multiple sclerosis (MS); however, limited reports are available on these comorbidities. We aimed to investigate the relationships among MS, anxiety, depression, and suicidal ideation.

Methods: One hundred and thirty two patients with relapsing-remitting MS were evaluated using the Expanded Disability Status Scale, Beck Depression Inventory-II (BDI-II), Beck Scale for Suicide Ideation (BSI), and Hospital Anxiety and Depression Scale.

Results: A hierarchical regression analysis was performed to evaluate the variables. The regression equation significantly predicted the BSI score (R2 = 0.306; adjusted R2 = 0.273; F (9, 125) = 9.18; p < 0.0005), and the BDI-II score was the only variable that contributed significantly to this model (p < 0.0005).

Conclusions: A high prevalence of depression and anxiety, and a higher rate of suicidal ideation were identified in MS patients compared to the general population. The presence of depressive symptoms appeared to have a direct influence on the risk of suicide.

RESUMO

Transtornos psiquiátricos frequentemente ocorrem em pacientes com esclerose múltipla (EM). No entanto, os artigos sobre estas comorbidades são limitados. Pretendemos investigar as relações entre EM, ansiedade, depressão e ideação suicida.

Métodos: Cento e trinta e dois pacientes com EM remitente-recorrente foram avaliados usando a Escala de Estado de Incapacidade Expandida, Inventário de Depressão de Beck-II (IDB-II), Escala de Beck para Ideação de Suicídio (BSI) e Escala de Ansiedade e Depressão.

Resultados: Uma análise de regressão hierárquica foi realizada para avaliar as variáveis. A equação de regressão previu significativamente o escore BSI (R2 = 0,306; R2 ajustado = 0,273; F (9,125) = 9,18; p < 0,0005) e o escore no IDB-II foi a única variável que contribuiu significativamente para este modelo (p < 0,0005).

Conclusões: Uma alta prevalência de depressão e ansiedade e uma maior taxa de ideação suicida foram identificadas em pacientes com EM em comparação com a população em geral. A presença de sintomas depressivos pareceu ter uma influência direta no risco de suicídio.

Keywords:

multiple sclerosis - suicidal ideation - anxiety - depression - risk factors - signs and symptoms

Palavras-chave:

esclerose múltipla - ideação suicida - ansiedade - depressão - fatores de risco - sinais e sintomas


Publication History

Received: 19 September 2017

Accepted: 03 February 2018

Article published online:
25 August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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