Risk of simultaneous phenotypic expression of hip and elbow dysplasia in dogs

Summary

In order to look for phenotypic correlation between hip (HD) and elbow (ED) dysplasia, we used radiographic scoring obtained from 1,411 dogs of different breeds, which were evaluated for authoritative grading of both conditions. In this population, we found that the risk ratio for an animal to be simultaneously affected by HD and ED is 1.67. For a dog with ED, the risk ratio to be affected by HD increases as the ED grade increases. Similarly, for a dog affected by HD, the risk ratio to be affected by ED increases as the HD grade increases. In a dog affected by HD or ED, the clinician should look for the second condition in the same animal. Due to the low, yet positive correlation, selection against one trait will not affect the other trait sufficiently. Therefore selection has to be conducted at reduction of HD as well as reduction of ED.

Keywords

Hip dysplasia - elbow dysplasia - dog - radio-graphic screening - correlation

• References

• 1 Janutta V, Distl O.. Inheritance of canine hip dysplasia: review of estimation methods and of heritability estimates and prospects on further developments. Dtsch Tierarztl Wochenschr 2006; 113 (01) 6-12.
• 2 Janutta V, Distl O.. Review on canine elbow dysplasia: pathogenesis, diagnosis, prevalence and genetic aspects. Dtsch Tierarztl Wochenschr 2008; 115 (05) 172-181.
• 3 Janutta V, Hamann H, Kein S. et al. Genetic analysis of three different classification protocols for the evaluation of elbow dysplasia in German shepherd dogs. J Small Anim Pract 2006; 47 (02) 75-82.
• 4 Maki K, Janss LL, Groen AF. et al An indication of major genes affecting hip and elbow dysplasia in four Finnish dog populations. Heredity 2004; 92 (05) 402-408.
• 5 Maki K, Liinamo AE, Ojala M.. Estimates of genetic parameters for hip and elbow dysplasia in Finnish Rottweilers. J Anim Sci 2000; 78 (05) 1141-1148.
• 6 Lang J, Busato A, Baumgartner D. et al Comparison of two classification protocols in the evaluation of elbow dysplasia in the dog. J Small Anim Pract 1998; 39 (04) 169-174.
• 7 Wosar MA, Lewis DD, Neuwirth L. et al Radiographic evaluation of elbow joints before and after surgery in dogs with possible fragmented medial coronoid process. J Am Vet Med Assoc 1999; 214 (01) 52-58.
• 8 Zhang J.. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcome. JAMA 1998; 280: 1690-1691.
• 9 Genevois JP, Remy D, Viguier E. et al. Prevalence of hip dysplasia according to official radiographic screening, among 31 breeds of dogs in France. Vet Comp Orthop Traumatol 2008; 21 (01) 21-24.
• 10 Remy D, Neuhart L, Fau D. et al Canine elbow dysplasia and primary lesions in German shepherd dogs in France. J Small Anim Pract 2004; 45 (05) 244-248.
• 11 Orthopedic Foundation for Animals. Elbow Dysplasia Statistics (search of OFA records) (document on internet). Orthopedic Foundation for Animals; 2009 (cited on 2009 June 29). Avalaible from http://www.offa.org/elbowstatbreed.html
• 12 Janutta V, Distl O.. Review on canine elbow dysplasia : pathogenesis, diagnosis, prevalence and genetic aspects. Dtsch Tierarztl Wochenschr. 2008 115. 172-181.
• 13 Beuing R, Janssen N, Wurster H. et al. The significance of elbow dysplasia (ED) for breeding in Bernese Mountain Dogs in Germany. Schweiz Arch Tierheilkd 2005; 147: 491-497.
• 14 Heine A, Hamann H, Telhelm B. et al Estimation of population genetic parameters and breeding values for elbow dysplasia in rottweilers. Berl Munch Tierarztl Wochenschr 2009; 122: 100-107.
• 15 Ohlerth S, Busato A, Gaillard C. et al. Epidemiologische und genetische Untersuchungen zur Hüftgelenksdysplasie an einer Population von Labrador Retriever: Eine Study über 25 Jahre. Dtsch Tierarztl Wochenschr 1998; 105: 378-383.
• 16 Sturaro E, Menegazzo L, Piccinini P. et al. Prevalence and genetic parameters for hip dysplasia in Italian population of purebred dogs. Ital J Anim Sci 2006; 5: 107-116.
• 17 Lafond E., Breur GJ, Austin CC.. Breed susceptibility for developmental orthopedic diseases in dogs. J Am Anim Hosp Assoc 2002; 38: 467-477.