Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case–control study

Ersin çintesun; Serra Akar; Ayhan Gul; Feyza Nur Incesu Çintesun; Gözde Sahin; Huriye Ezveci; Fikret Akyürek; Çetin Çelik

doi:10.4103/JLP.JLP_151_18

Journal of Laboratory Physicians, Table of Contents

CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(02): 149-153
DOI: 10.4103/JLP.JLP_151_18

Original Article

Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case–control study

Ersin çintesun

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Serra Akar

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Ayhan Gul

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Feyza Nur Incesu Çintesun

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Gözde Sahin

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Huriye Ezveci

Department of Biochemistry, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Fikret Akyürek

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

,

Çetin Çelik

Department of Obstetrics and Gynecology, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey, India

› Author Affiliations

Abstract

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Abstract

INTRODUCTION: Subclinical inflammation markers play a significant role in hyperemesis gravidarum (HEG). Simple hematological markers such as mean platelet volume (MPV), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), plateletcrit (PCT), and platelet-to-lymphocyte ratio (PLR) have been shown to reflect inflammatory burden and disease activity in several disorders. Ketonuria is a parameter used in the diagnosis of severe HEG, but its correlation with disease severity remains controversial. The relationship of subclinical inflammation markers with degree of ketonuria has not been examined previously. In this study, we aimed to determine the diagnostic value of these subclinical inflammation markers and the relationship between these markers and grade of ketonuria in patients with HEG.

MATERIALS AND METHODS: A total of 94 pregnant women with a diagnosis of HEG and 100 gestational age-matched healthy pregnant women were enrolled in this retrospective study. MPV, PDW, NLR, PLR, PCT, and ketonuria were calculated and analyzed from complete blood cell counts and total urine analyses.

RESULTS: Lymphocyte count was significantly higher in the control group (P < 0,001); NLR and PLR values were significantly higher in the HEG group (P < 0,001). Among inflammation markers, RDW increased significantly (P = 0,008) with an increase in ketonuria in patients with HEG. A statistically significant correlation was found between white blood cell (WBC) and NLR, PLR, PCT. A moderate uphill relationship was observed between NLR and WBC and a weak uphill linear relationship was observed between WBC and PLR and between WBC and PCT

CONCLUSIONS: PLR and NLR can be considered effective markers to aid in the diagnosis of HEG. No marker was found to correlate with ketonuria grade except RDW, although the relationship of the severity of ketonuria with severity of disease is controversial. RDW increases as the degree of ketonuria increases.

Key words

Hyperemesis gravidarum - ketonuria - subclinical inflammation

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References

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