Modified 5-fluorouracil/leucovorin/irinotecan as a feasible and efficacious second-line chemotherapeutic regimen in advanced gastric cancers

Anant Ramaswamy; Vikas Ostwal; Kushal Gupta; Vijai Simha; Anup Toshniwal; Nitin Shetty; Chaitali Nashikkar; Sarika Mandavkar; Sudeep Gupta

doi:10.4103/sajc.sajc_232_17

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2018; 07(04): 219-222
DOI: 10.4103/sajc.sajc_232_17

ORIGINAL ARTICLE: GI Cancers

Modified 5-fluorouracil/leucovorin/irinotecan as a feasible and efficacious second-line chemotherapeutic regimen in advanced gastric cancers

Authors

Anant Ramaswamy

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Vikas Ostwal

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Kushal Gupta

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Vijai Simha

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Anup Toshniwal

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Nitin Shetty

Department of Radiology, Tata Memorial Hospital, Mumbai, Maharashtra
Chaitali Nashikkar

Department of GIDMG, Tata Memorial Hospital, Mumbai, Maharashtrar
Sarika Mandavkar

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Sudeep Gupta

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

Abstract

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Abstract

Background: Modified 5-fluorouracil/leucovorin/irinotecan (mFOLFIRI) is a commonly used combination second-line chemotherapeutic regimen in advanced gastric cancer (AGC). Materials and Methods: Patients diagnosed with AGC, receiving biweekly mFOLFIRI between July 2013 and June 2016, as second-line chemotherapy were retrospectively analyzed for tolerance, prognostic factors, event-free survival (EFS), and overall survival (OS). Results: Overall, 91 patients were administered a median of 6 cycles of therapy. Response rate was 29.7% and clinical benefit rate was 57.2%. With a median follow-up of 11.5 months, median EFS was 3.98 months (95% confidence interval [CI]: 2.54–5.41) and median OS was 7.73 months (95% CI: 5.30–10.15). Common Grade 3 and Grade 4 adverse events were neutropenia (18.7%), febrile neutropenia (9.9%), thrombocytopenia (7.7%), and vomiting (4.4%). Nearly 33% of patients required dose modification during therapy. Conclusions: mFOLFIRI regimen as a second-line therapy in AGCs appears feasible and efficacious in clinical practice.

Key words

Advanced gastric cancers - modified 5-fluorouracil/leucovorin/irinotecan - second-line chemotherapy

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References

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