10 Medical Treatment of Male and Female Pattern Hair Loss

Nicole E. Rogers and Aditya K. Gupta

Summary

While the title of this book is Hair Transplantation, it is essential to include medical therapy in the discussion with our patients. It can be just as important in the overall improvement of our patients’ appearance and quality of life. In this chapter, we cover the most commonly prescribed medical treatments for hair loss: minoxidil, finasteride, dutasteride, low-level laser light therapy, and platelet-rich plasma. We also discuss the relative benefits and side effects of each.

Schlüsselwörter

minoxidil - finasteride - dutasteride - laser - platelet-rich plasma - camouflage

• 1 Burton JL, Marshall A. Hypertrichosis due to minoxidil.. Br J Dermatol 1979; 101 (5) 593-595 PubMed

• 2 Zappacosta AR. Reversal of baldness in patient receiving minoxidil for hypertension.. N Engl J Med 1980; 303 (25) 1480-1481 PubMed

• 3 Vanderveen EE, Ellis CN, Kang S et al. Topical minoxidil for hair regrowth.. J Am Acad Dermatol 1984; 11 (3) 416-421 PubMed

• 4 Buhl AE, Baker CA, Dietz AJ. Minoxidil sulfotransferase activity influences the efficacy of Rogaine topical solution (TS): enzyme studies using scalp and platelets.. J Invest Dermatol 1994; 102: 534

• 5 Baden HP, Kubilus J. Effect of minoxidil on cultured keratinocytes.. J Invest Dermatol 1983; 81 (6) 558-560 PubMed

• 6 Uno H, Mori O, Cappas A, Buys CM, Fiedler-Weiss VC. The effect of topical minoxidil on sequential histological changes in alopecia totalis and universalis.. J Invest Dermatol 1986; 86: 512

• 7 Abell E. Histologic response to topically applied minoxidil in male-pattern alopecia.. Clin Dermatol 1988; 6 (4) 191-194 PubMed

• 8 Olsen EA, Whiting D, Bergfeld W et al. A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men.. J Am Acad Dermatol 2007; 57 (5) 767-774 PubMed

• 9 Bergfeld W, Washenik K, Callender V et al. Phase-III, multicenter, parallel-design clinical trial to compare the efficacy and safety of 5% minoxidil foam versus vehicle in women with female pattern hair loss.. J Drugs Dermatol 2016; 15 (7) 874-881 PubMed

• 10 Bluem-Peytavi U, Hillmann K, Dietz E, Canfield D, Garcia Bartels N.. A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. J Am Acad Dermatol 2011; 65: 1126-1134

• 11 Kanti V, Hillmann K, Kottner J, Stroux A, Canfield D, Blume-Peytavi U. Effect of minoxidil topical foam on frontotemporal and vertex androgenetic alopecia in men: a 104-week open-label clinical trial.. J Eur Acad Dermatol Venereol 2016; 30 (7) 1183-1189 PubMed

• 12 Bouhanna P. Topical minoxidil used before and after hair transplantation. J Dermatol Surg Oncol. 1989;15(1):50–53

• 13 Avram MR, Cole JP, Gandelman M, et al. The potential role of minoxidil in the hair transplantation setting.. Dermatol Surg 2002; 28 (10) 894-900, discussion 900 PubMed

• 14 Friedman ES, Friedman PM, Cohen DE, Washenik K. Allergic contact dermatitis to topical minoxidil solution: etiology and treatment.. J Am Acad Dermatol 2002; 46 (2) 309-312 PubMed

• 15 Sinclair RD. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Int J Dermatol. 2018;57(1):104–109

• 16 Ramos PM, Sinclair RD, Kasprzak M, Miot HA. Minoxidil 1 mg oral versus minoxidil 5% topical solution for the treatment of female-pattern hair loss: A randomized clinical trial. J Am Acad Dermatol. 2020;82(1):252–253

• 17 Dallob AL, Sadick NS, Unger W et al. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.. J Clin Endocrinol Metab 1994; 79 (3) 703-706 PubMed

• 18 Drake L, Hordinsky M, Fiedler V et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.. J Am Acad Dermatol 1999; 41 (4) 550-554 PubMed

• 19 Propecia Package insert

• 20 Kaufman KD, Olsen EA, Whiting D, et al. Finasteride in the treatment of men with androgenetic alopecia.. J Am Acad Dermatol 1998; 39 (4, Pt 1) 578-589 PubMed

• 21 Kaufman KD. Merck Research Laboratories (The Finasteride Male Pattern Hair Loss Study Group) Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia.. Eur J Dermatol 2002; 12: 38-49

• 22 Leyden J, Dunlap F, Miller B et al. Finasteride in the treatment of men with frontal male pattern hair loss.. J Am Acad Dermatol 1999; 40 (6, Pt 1) 930-937 PubMed

• 23 Leavitt M, Perez-Meza D, Rao NA, Barusco M, Kaufman KD, Ziering C. Effects of finasteride (1 mg) on hair transplant.. Dermatol Surg 2005; 31 (10) 1268-1276, discussion 1276 PubMed

• 24 Van Neste D, Fuh V, Sanchez-Pedreno P et al. Finasteride increases anagen hair in men with androgenetic alopecia.. Br J Dermatol 2000; 143 (4) 804-810 PubMed

• 25 Price VH, Menefee E, Sanchez M, Ruane P, Kaufman KD. Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily.. J Am Acad Dermatol 2002; 46 (4) 517-523 PubMed

• 26 Price VH, Menefee E, Sanchez M, Kaufman KD. Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results.. J Am Acad Dermatol 2006; 55 (1) 71-74 PubMed

• 27 Price VH, Roberts JL, Hordinsky M et al. Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia.. J Am Acad Dermatol 2000; 43 (5, Pt 1) 768-776 PubMed

• 28 Yeon JH, Jung JY, Choi JW et al. 5 mg/day finasteride treatment for normoandrogenic Asian women with female pattern hair loss.. J Eur Acad Dermatol Venereol 2011; 25 (2) 211-214 PubMed

• 29 Oliveira-Soares R, E Silva JM, Correia MP, André MC. Finasteride 5 mg/day treatment of patterned hair loss in normo-androgenetic postmenopausal women.. Int J Trichology 2013; 5 (1) 22-25 PubMed

• 30 D’Amico AV, Roehrborn CG. Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial.. Lancet Oncol 2007; 8 (1) 21-25 PubMed

• 31 Thompson IM, Goodman PJ, Tangen CM et al. The influence of finasteride on the development of prostate cancer.. N Engl J Med 2003; 349 (3) 215-224 PubMed

• 32 Samplaski MK, Lo K, Grober E, Jarvi K. Finasteride use in the male infertility population: effects on semen and hormone parameters.. Fertil Steril 2013; 100 (6) 1542-1546 PubMed

• 33 Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML. Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.. J Sex Med 2011; 8 (3) 872-884 PubMed

• 34 Bird ST, Brophy JM, Hartzema AG, Delaney JA, Etminan M. Male breast cancer and 5α -reductase inhibitors finasteride and dutasteride.. J Urol 2013; 190 (5) 1811-1814 PubMed

• 35 Duijnhoven RG, Straus SM, Souverein PC et al. Long-term use of 5 α-reductase inhibitors and the risk of male breast cancer.. Cancer Causes Control 2014; 25 (11) 1577-1582 PubMed

• 36 Boyapati A, Sinclair R. Combination therapy with finasteride and low-dose dutasteride in the treatment of androgenetic alopecia.. Australas J Dermatol 2013; 54 (1) 49-51 PubMed

• 37 Gubelin Harcha W, Barboza Martínez J, Tsai TF et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia.. J Am Acad Dermatol 2014; 70 (3) 489-498.e3 PubMed

• 38 Olszewska M, Rudnicka L. Effective treatment of female androgenic alopecia with dutasteride.. J Drugs Dermatol 2005; 4 (5) 637-640 PubMed

• 39 Seale LR, Eglini AN, McMichael AJ. Side effects related to 5-alpha reductase inhibitor treatment of hair loss in women: a review.. J Drugs Dermatol 2016; 15 (4) 414-419 PubMed

• 40 Huang Y-Y, Chen AC-H, Carroll JD, Hamblin MR. Biphasic dose response in low level light therapy.. Dose Response 2009; 7 (4) 358-383 PubMed

• 41 Kim T-H, Kim N-J, Youn J-I. Evaluation of wavelength-dependent hair growth effects on low-level laser therapy: an experimental animal study.. Lasers Med Sci 2015; 30 (6) 1703-1709 PubMed

• 42 Sheen Y-S, Fan SM-Y, Chan C-C, Wu YF, Jee SH, Lin SJ. Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro.. Lasers Surg Med 2015; 47 (1) 50-59 PubMed

• 43 Jimenez JJ, Wikramanayake TC, Bergfeld W et al. Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, double-blind study.. Am J Clin Dermatol 2014; 15 (2) 115-127 PubMed

• 44 Kim H, Choi JW, Kim JY, Shin JW, Lee SJ, Huh CH. Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, sham device-controlled multicenter trial.. Dermatol Surg 2013; 39 (8) 1177-1183 PubMed

• 45 Lanzafame RJ, Blanche RR, Bodian AB, Chiacchierini RP, Fernandez-Obregon A, Kazmirek ER. The growth of human scalp hair mediated by visible red light laser and LED sources in males.. Lasers Surg Med 2013; 45 (8) 487-495 PubMed

• 46 Lanzafame RJ, Blanche RR, Chiacchierini RP, Kazmirek ER, Sklar JA. The growth of human scalp hair in females using visible red light laser and LED sources.. Lasers Surg Med 2014; 46 (8) 601-607 PubMed

• 47 Gupta AK, Foley KA. A critical assessment of the evidence for low-level laser therapy in the treatment of hair loss.. Dermatol Surg 2017; 43 (2) 188-197 PubMed

• 48 Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery.. Plast Reconstr Surg 2006; 118 (6) 1458-1466, discussion 1467 PubMed

• 49 Trink A, Sorbellini E, Bezzola P et al. A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata.. Br J Dermatol 2013; 169 (3) 690-694 PubMed

• 50 Schiavone G, Raskovic D, Greco J, Abeni D. Platelet-rich plasma for androgenetic alopecia: a pilot study.. Dermatol Surg 2014; 40 (9) 1010-1019 PubMed

• 51 Puig CJ, Reese R, Peters M. Double-blind, placebo-controlled pilot study on the use of platelet-rich plasma in women with female androgenetic alopecia.. Dermatol Surg 2016; 42 (11) 1243-1247 PubMed