27.27 Product Class 27: 1,2-Diimines
Book
Editors: Fernández, E.; Huang, Z.; Jiang, X.; Koch, G.; Marschner, C.; Wang, M.
Title: Knowledge Updates 2021/2
Print ISBN: 9783132442061; Online ISBN: 9783132442085; Book DOI: 10.1055/b000000477
1st edition © 2021 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Knowledge Updates
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract
![](https://www.thieme-connect.de/media/10.1055-b000000477/thumbnails/a_102abd.jpg)
The utility of 1,2-diimines (α-diimines, 1,4-diazabutadienes) stems from the ease with which their steric and electronic properties can be tailored to a specific use. Current interest in this area involves using 1,2-diimines as precursors for novel bioactive compounds, as well as transition-metal ligands for the formation of novel polymerization catalysts and chemotherapeutic agents. In this review, the fundamental approaches for the synthesis of 1,2-diimines are described, as well as a current sampling of the unique ways that they are used to solve research problems. The chapter is organized based on the ways that 1,2-diimines are synthesized: condensation reactions and metal-promoted methods.
Key words
diimines - azomethines - Schiff bases - diketones - anilines - condensation reactions- 5 Armesta D, Bosch P, Gallegho MG, Martin JF, Ortiz MJ, Perez-Ossorio R, Ramos A. Org. Prep. Proced. Int. 1987; 19: 181
- 9 Tran CC, Kawaguchi S.-i, Kobiki Y, Matsubara H, Tran DP, Kodama S, Nomoto A, Ogawa A. J. Org. Chem. 2019; 84: 11 741
- 18 Faust R, Göbelt B, Weber C, Krieger C, Gross M, Gisselbrecht J.-P, Boudon C. Eur. J. Org. Chem. 1999; 1999: 205
- 19 World Health Organization Model List of Essential Medicines, 21st List, 2019. World Health Organization; Geneva 2019. Accessed January , 2021 at: www.who.int/publications/i/item/WHOMVPEMPIAU2019.06
- 22 Ginzinger W, Mühlgassner G, Arion VB, Jakupec MA, Roller A, Galanski M, Reithofer M, Berger W, Keppler BK. J. Med. Chem. 2012; 55: 3398
- 27 Falivene L, Credendino R, Poater A, Petta A, Serra L, Oliva R, Scarano V, Cavallo L. Organometallics 2016; 35: 2286
- 35 Biancalana L, Batchelor LK, Dyson PJ, Zacchini S, Schoch S, Pampaloni G, Marchetti F. New J. Chem. 2018; 42: 17 453
- 40 Abakumov GA, Cherkasov VK, Druzhkov NO, Kurskii YA, Fukin GK, Abakumova LG, Kocherova TN. Synth. Commun. 2006; 36: 3241
- 42 Brown LA, Wekesa FS, Unruh DK, Findlater M, Long BK. J. Polym. Sci., Part A: Polym. Chem. 2017; 55: 2824
- 47 Rizzo RC, Udier-Blagovicë M, Wang D.-P, Watkins EK, Kroeger Smith MB, Smith RH, Tirado-Rives J, Jorgensen WL. J. Med. Chem. 2002; 45: 2970