34.9.2 β-Fluoro Alcohols (Update 2013)

Abstract

This manuscript is an update to the earlier Science of Synthesis contribution describing methods for the synthesis of β-fluoro alcohols. It focuses on the literature published in the period 2005–2012. Routes discussed include epoxide opening by fluoride, reduction of α-fluoro ketones, fluoromethylation of aldehydes, and hydroxyfluorination of alkenes. Special attention is given to the stereoselective synthesis of β-fluoro alcohols.

Key words

alkene hydroxyfluorination - asymmetric synthesis - carbon-halogen bonds - carbonyl fluoromethylation - desulfonylation - epoxide ring opening - fluorides - fluorine compounds - β-fluoro alcohols - stereoselective synthesis - transfer hydrogenation

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