34.1.4.3 Synthesis of Fluoroalkanes by Substitution of Oxygen and Sulfur Functionalities

Abstract

This chapter is a revision of the earlier Science of Synthesis contribution describing methods for the synthesis of fluoroalkanes by substitution of oxygen and sulfur functionalities. It now includes the literature published up until 2016. The additional material focuses on new reagents and their applications. For example, the effect of an ionic liquid on the rate of the displacement of sulfonates by cesium fluoride, and expeditious synthesis of nucleoside derivatives are described.

Key words

fluoroalkanes - nucleophilic substitution - fluorides - sulfonates - alkanes - cycloalkanes - pyrans - nucleosides - carbohydrates - steroids - sulfur compounds - copper complexes

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