34.1.6.4 Synthesis of Fluoroalkanes with Retention of the Functional Group (Update 2017)

T. Yamazaki

Abstract

This chapter is an update to the earlier Science of Synthesis contribution (Section 34.1.6) describing methods for the synthesis of monofluorinated compounds with a C(sp³)—F bond by way of a wide variety of transformations of molecules already bearing the key C—F bond. The focus is on methods published in the period 2005–2015.

Key words

alkylation - crossed aldol reactions - conjugate addition - SN2′ reactions - hydrogenation - reduction - cycloadditions - iodolactonization

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