2.4 Silicon-Mediated Multicomponent Reactions

J. Wan

Abstract

Silicon reagents are commonly employed in organic synthesis as catalysts or promoters because of their availability and versatile catalytic activity. Some typical silicon reagents, such as trimethylsilyl halides (where the halide is chlorine or iodine) or trimethylsilyl trifluoromethanesulfonate, are known to be capable of acting as Lewis acids, Brønsted acids (upon hydrolysis), and water scavengers. This section presents an overview of the particularly broad application of silicon reagents in multicomponent reactions. Silicon-mediated multicomponent processes that lead to both cyclic and acyclic products are summarized.

Schlüsselwörter

Biginelli reactions - cyclization reactions - 1,3-dicarbonyl compounds - imidazoles - pyridine synthesis - quinoxalines - silicon reagents - tetrahydropyridinones - 1,3-thiazines

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