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van Leeuwen, P. W. N. M.: 2014 Science of Synthesis, 2013/7: C-1 Building Blocks in Organic Synthesis 1 DOI: 10.1055/sos-SD-212-00003
C-1 Building Blocks in Organic Synthesis 1

1.1.1 Hydroformylation of Alkenes

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Book

Editor: van Leeuwen, P. W. N. M.

Authors: Ballini, R.; Belderrain, T. R.; Bronger, R. P. J.; Clarke, M. L.; Claver, C.; de Vries, J. G.; Feng, X. M.; Fleischer, I.; Fuentes, J. A.; Godard, C.; Goldfuss, B.; Iwasawa, N.; Kamer, P. C. J.; Lin, L. L.; Liu, X. H.; Mejía, E.; Monflier, E.; Mortreux, A.; Nicasio, M. C.; Perandones, B. F.; Petrini, M.; Sauthier, M.; Takaya, J.; Tauchert, M. E.; Tilloy, S.; Vogt, D.

Title: C-1 Building Blocks in Organic Synthesis 1

Subtitle: Additions to Alkenes, Alkynes, and Carbonyl Compounds

Print ISBN: 9783131707611; Online ISBN: 9783132064416; Book DOI: 10.1055/b-003-125818

1st edition © 2014. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: C-1 Building Blocks in Organic Synthesis

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Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Type: Multivolume Edition

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Abstract

Hydroformylation of alkenes is a mild and clean method for the functionalization of hydrocarbons and has grown to be among the most important homogeneously catalyzed reactions in industry. It is a 100% atom-economic reaction to prepare aldehydes that are important synthons for organic synthesis, and has wide functional group compatibility.

In this review the focus is on the effects of various catalysts on the selective hydroformylation of both functionalized and unfunctionalized alkenes to produce high-value aldehydes. In particular, rhodium catalysts have undergone a remarkable development, while cobalt catalysts have remained more or less unchanged over the years, and palladium has recently been recognized as a suitable transition metal for hydroformylation.

Key words

hydroformylation - homogeneous catalysis - aldehydes - phosphorus ligands - ligand design - rhodium - cobalt - palladium - platinum
 
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