2.6. 2 Difluoro- and Fluoromethylation
Book
Editor: van Leeuwen, P. W. N. M.
Title: C-1 Building Blocks in Organic Synthesis 2
Subtitle: Alkenations, Cross Couplings, Insertions, Substitutions, and Halomethylations
Print ISBN: 9783131751218; Online ISBN: 9783132064515; Book DOI: 10.1055/b-003-125817
1st edition © 2014. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: C-1 Building Blocks in Organic Synthesis
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Type: Multivolume Edition
Abstract
This chapter summarizes the currently known synthetically useful difluoro- and fluoromethylation methods employing various fluorinated C-1 building blocks. The classical routes to difluoro- and fluoromethyl compounds are direct nucleophilic, electrophilic, and free-radical reactions, but more recent developments involving fluoroalkyl transition-metal species are also included.
Key words
difluoromethyl compounds - difluoromethylation - fluoromethyl compounds - fluoromethylation - fluoroalkylation - nucleophilic reaction - electrophilic reaction - radical reaction - cross-coupling reactions - auxiliary groups - transition metals - asymmetric synthesis - sulfones - desulfonylation - desulfanylation - dephosphorylation - dehalogenation - sulfoximides - sulfonium salts - iodonium compounds - silanes-
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