1.3.1 Resolution of Alcohols, Acids, and Esters by Hydrolysis

M. Bertau; G. E. Jeromin

Abstract

This chapter reviews the use of enzymes, principally esterases and lipases, as catalysts for the resolution of racemic carboxylic acid derivatives via hydrolysis. The resolution of esters of chiral primary, secondary, and tertiary alcohols, as well as diols, are examined. Biocatalytic hydrolytic methods for the desymmetrization of prochiral substrates and meso-compounds are also considered.

Key words

carboxylic acids - carboxylic esters - alcohols - diols - resolution - esterase - lipase - hydrolysis - meso-trick - desymmetrization - dynamic kinetic resolution - substrate engineering - substrate design

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