1.6.1 Glycosidases and Glycosynthases

B. Cobucci Ponzano; M. Moracci

doi:10.1055/sos-SD-214-00371

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Faber, K. et al.: 2015 Science of Synthesis, 1: Biocatalysis in Organic Synthesis 1 DOI: 10.1055/sos-SD-214-00371

Biocatalysis in Organic Synthesis 1

1.6.1 Glycosidases and Glycosynthases

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Editors: Faber, K.; Fessner, W.-D.; Turner, N. J.

Authors: Asano, Y.; Babich, L.; Bertau, M.; Cobucci-Ponzano, B.; Díaz-Rodríguez, A.; Engel, U.; Faber, K.; Flitsch, S. L.; Glueck, S. M.; Gotor-Fernández, V.; Green, A. P.; Hall, M.; Hartog, A. F.; Hepworth, L. J.; Hollmann, F.; Jeromin, G. E.; Lauchli, R.; Lavandera, I.; Liese, A.; Martínková, L.; Moracci, M.; Pesci, L.; Rodríguez-Mata, M.; Rozzell, D.; Rudat, J.; Schmidberger, J. W.; Servi, S.; Slomka, C.; Syldatk, C.; Tasnádi, G.; Tessaro, D.; Veselá, A. B.; Voglmeir, J.; Wever, R.

Title: Biocatalysis in Organic Synthesis 1

Print ISBN: 9783131741318; Online ISBN: 9783131975218; Book DOI: 10.1055/b-003-125815

1st edition © 2015. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry

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Title: Science of Synthesis

DOI: 10.1055/b-00000101

Type: Multivolume Edition

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B. Cobucci Ponzano; M. Moracci

Abstract

Enzymatic synthesis of glycans, as an alternative to classical chemical synthesis, is of great interest due to the exquisite stereospecificity and improved processivity and regioselectivity of the biological catalysts, and for the possibility of using reagents less toxic to the environment. Nonetheless, the limitations intrinsic to the natural enzymes promoting sugar synthesis, namely glycoside hydrolases and glycosyltransferases, have prompted efforts to engineer the former catalysts, obtaining glycosynthases that promote the synthesis of oligosaccharides, polysaccharides, and glycoconjugates in quantitative yields from inexpensive substrates. In this chapter we survey methods that exploit glycosidases and glycosynthases to allow the efficient and reliable preparation of glycans of synthetic relevance.

Key words

carbohydrate active enzymes - carbohydrate synthesis - enzyme engineering - glycobiology - glycochemistry - glycoconjugates - glycosidase reaction mechanism - glycosyltransferase - oligosaccharides - polysaccharides - protein glycosylation

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