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Snyder, S. A.: 2016 Science of Synthesis, 2015/4a: Applications of Domino Transformations in Organic Synthesis 1 DOI: 10.1055/sos-SD-219-00294
Applications of Domino Transformations in Organic Synthesis 1

1.6.5 Cobalt and Other Metal Mediated Domino Reactions: The Pauson–Khand Reaction and Its Use in Natural Product Total Synthesis

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Buch

Herausgeber: Snyder, S. A.

Autoren: Adu-Ampratwum, D.; Anderson, E.; Armbrust, K. W.; Devery, J.; Douglas, J.; Doyle, M. P.; Engle, K. M.; Forsyth, C. J.; Gille, F.; Halkina, T.; Hu, X.; Jamison, T.; Kelley, E. H.; Kirschning, A.; Lee, D.; Maimone, T.; Merino, E.; Nevado Blazquez, C.; O'Connor, M. J.; Ohshima, T.; Parker, K.; Renata, H.; Salvador, A.; Schaumann, E.; Shenvi, R.; Shi, L.-L.; Sittihan, S.; Snyder, S. A.; Stephenson, C. R. J.; Tang, M.; Truong, P.; Tu, Y.-Q.; Wan, K.; Wang, S.-H.; Wolling, M.; Xu, X.; Yang, Z.

Titel: Applications of Domino Transformations in Organic Synthesis 1

Print ISBN: 9783131731319; Online ISBN: 9783132402522; Buch-DOI: 10.1055/b-003-128286

1st edition © 2016. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie

Science of Synthesis Reference Libraries



Übergeordnete Publikation

Titel: Science of Synthesis

DOI: 10.1055/b-00000101

Reihenherausgeber: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.

Typ: Mehrbändiges Werk

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Abstract

The Pauson–Khand reaction constitutes one of the most formidable additions to the repertoire of synthetically useful reactions. It rapidly affords a cyclopentenone skeleton from an alkene, an alkyne, and carbon monoxide, based on a domino sequence of bond constructions. In this chapter, the prowess of the Pauson–Khand reaction is illustrated by judicious selection of complex target molecules, the total syntheses of which are cleverly orchestrated by the key Pauson–Khand reaction sequence. Emphasis is placed on cobalt-mediated processes to exemplify the applicability of this classical reaction.

Schlüsselwörter

Pauson–Khand reaction - alkenes - carbon monoxide - alkynes - cyclopentenones - natural product synthesis - octacarbonyldicobalt - thioureas - allenic alkynes - asymmetric synthesis
 
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