Gao, S. et al.: 2016 Science of Synthesis, 2016/4b: Metal-Catalyzed Cyclization Reactions 2 DOI: 10.1055/sos-SD-222-00001
Metal-Catalyzed Cyclization Reactions 2

2.1 Epoxidation and Aziridination Reactions

Weitere Informationen

Buch

Herausgeber: Gao, S.; Ma, S.

Autoren: Bora, U.; Dominguez, G.; Du, H.; Garve, L.; Harmata, M.; Hu, W.; Jones, D. E.; Lee, D.; Li, X.; Mondal, M.; Pérez Castells, J.; Sabbasani, V. R.; Shibata, Y.; Tanaka, K.; Tang, W.; Werz, D. B.; Xia, F.; Xu, X.; Ye, S.

Titel: Metal-Catalyzed Cyclization Reactions 2

Print ISBN: 9783131998118; Online ISBN: 9783132404823; Buch-DOI: 10.1055/b-004-129734

Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie

Science of Synthesis Reference Libraries



Übergeordnete Publikation

Titel: Science of Synthesis

DOI: 10.1055/b-00000101

Reihenherausgeber: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.

Typ: Mehrbändiges Werk

 


F. Xia; S. Ye

Abstract

Zoom

Due to the strain associated with three-membered rings, epoxides and aziridines react with various nucleophiles to give 1,2-difunctionalized products. This makes them valuable intermediates in organic synthesis, including in the synthesis of bioactive natural and nonnatural compounds. This chapter summarizes recent advances in metal-catalyzed epoxidation and aziridination reactions of alkenes, as well as their synthetic applications.

 
  • 24 Zhang W, Loebach JL, Wilson SR, Jacobsen EN. J. Am. Chem. Soc. 1990; 112: 2801
  • 80 Subbarayan V, Ruppel JV, Zhu S, Perman JA, Zhang XP. Chem. Commun. (Cambridge) 2009; 4266
  • 84 Vacca JP, Dorsey BD, Schleif WA, Levin RB, McDaniel SL, Darke PL, Zugay J, Quintero JC, Blahy OM, Roth E, Sardana V, Schlabach AJ, Graham PI, Condra JH, Gotlib L, Holloway MK, Lin J, Chen I.-W, Vastag K, Ostovic D, Anderson PS, Emini EA, Huff JR. Proc. Natl. Acad. Sci. U. S. A. 1994; 91: 4096