2.1 Epoxidation and Aziridination Reactions

F. Xia; S. Ye

Abstract

Due to the strain associated with three-membered rings, epoxides and aziridines react with various nucleophiles to give 1,2-difunctionalized products. This makes them valuable intermediates in organic synthesis, including in the synthesis of bioactive natural and nonnatural compounds. This chapter summarizes recent advances in metal-catalyzed epoxidation and aziridination reactions of alkenes, as well as their synthetic applications.

Schlüsselwörter

epoxidation - aziridination - expoxides - aziridines - alkenes - metal catalysis - cyclization - enantioselectivity - diastereoselectivity - asymmetric synthesis

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