2.9 Intramolecular Free-Radical Cyclization Reactions
Book
Editors: Gao, S.; Ma, S.
Title: Metal-Catalyzed Cyclization Reactions 2
Print ISBN: 9783131998118; Online ISBN: 9783132404823; Book DOI: 10.1055/b-004-129734
1st edition © 2016 Georg Thieme Verlag KG
Georg Thieme Verlag, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract
![](https://www.thieme-connect.de/media/10.1055-b-004-129734/thumbnails/a_212mcr.jpg)
Over the past five decades, the metal-mediated intramolecular free-radical cyclization strategy has developed into a widely applicable synthetic methodology. With properties including wide functional-group tolerance, selectivity, and spatial retention, radical chemistry has attracted considerable attention from chemists dealing with the synthesis and functionalization of diverse organic compounds. The coverage of this chapter is limited to the best methods available for the metal-mediated synthesis of cyclic organic and biomolecular species for practical use in both an academic setting and in industry.
Key words
intramolecular - free-radical - cyclization - manganese(III) acetate - titanocenes - samarium(II) iodide - copper - tandem - cascade - pyrroles - alkylidenes - indoles - azaindolines - indolinones - oxindoles - lactams - quinolines - furans - lactones - phthalides - pyrans - benzopyrans - piperidines - cycloalkanes - cycloalkanols - allyl alcohols - amino alcohols - cyclic ketones - amino ketones - phenanthridines - benzothiazoles - thiophenes - total synthesis- 5 Stereochemistry of Radical Reactions: Concepts, Guidelines, and Synthetic Applications. Curran DP, Porter NA, Giese B. VCH; Weinheim, Germany 1996
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