1.4. 5 Hydroamination
Book
Editors: Cazin, C. ; Nolan, S.
Title: N-Heterocyclic Carbenes in Catalytic Organic Synthesis 1
Print ISBN: 9783132012813; Online ISBN: 9783132407633; Book DOI: 10.1055/b-004-132254
1st edition © 2017. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract
Hydroamination, the addition of an N—H moiety across carbon–carbon unsaturation, is an attractive, atom-economical methodology for the synthesis of nitrogen-containing compounds. N-Heterocyclic and cyclic (alkyl)(amino)carbenes have been applied as supporting ligands for the synthesis of catalysts capable of mediating both inter- and intramolecular (cyclization) reactions with alkynes, allenes, and activated alkenes.
Key words
catalytic hydroamination - C—N bond formation - N-heterocyclic carbenes - cyclic (alkyl)(amino)carbenes - nitrogen heterocycles - pyrrolidines - piperidines - amines - imines - enamines - quinolines - 1,2-dihydroquinolines - benzo[b][1,4]diazepines- 7 Reznichenko, AL, Hultzsch, KC, In Chiral Amine Synthesis. Nugent, TC, ED. Wiley-VCH Weinheim, Germany 2010; p 341
- 23 Pouy, MJ, Delp, SA, Uddin, J, Ramdeen, VM, Cochrane, NA, Fortman, GC, Gunnoe, TB, Cundari, TR, Sabat, M, Myers, WH. ACS Catal.. 2012; 2: 2182
- 25 Schaper, L.-A, Wei, X, Hock, SJ, Pöthig, A, Öfele, K, Cokoja, M, Herrmann, WA, Kühn, FE. Organometallics. 2013; 32: 3376