5.3 Aminohydroxylation and Aminooxygenation of Alkenes
Book
Editor: Muñiz, K.
Title: Catalytic Oxidation in Organic Synthesis
Print ISBN: 9783132012318; Online ISBN: 9783132403710; Book DOI: 10.1055/b-003-129345
1st edition © 2018. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Koch, G.; Molander, G. A.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract
![](https://www.thieme-connect.de/media/10.1055-b-003-129345/thumbnails/a_214kml.jpg)
The aminohydroxylation of alkenes provides β-amino alcohols (vicinal amino alcohols). A number of alkene aminohydroxylation protocols (and those of related reactions termed oxyamination and aminooxygenation), predominantly enabled by transition-metal catalysis, are described in this chapter, which focuses on literature published in the period 1996–2015. Cyclic and acyclic compounds containing vicinal amino alcohols and derivatives thereof can be prepared from alkenes with good regio-, diastereo-, and enantioselectivity.
Key words
alkenes - aminooxygenation - aminohydroxylation - oxyamination - β-amino alcohols - catalysis - osmium catalysts - iron catalysts - rhodium catalysts - copper catalysts - palladium catalysts - manganese catalysts- 2 Zappia G, Menendez P, Delle Monache G, Misiti D, Nevola L, Botta B. Mini-Rev. Med. Chem. 2007; 7: 389
- 6 Muñiz K, In: Science of Synthesis: Stereoselective Synthesis de Vries JG. Thieme Stuttgart 2011; 1. 34
- 7 Bingham MJ, Greaney MF, In: Science of Synthesis Clayden J, Thomas EJ. Thieme Stuttgart 2008; 36. 1005