2.2 Transfer Hydrogenation of Ketones to Alcohols

A. Matsunami; Y. Kayaki; T. Ikariya

Abstract

Transfer hydrogenation offers an alternative to hydrogenation using gaseous hydrogen, as well as a practical synthetic approach to enantiopure compounds. Alcohols, formic acid, and formate salts are often used as safe and nontoxic hydrogen sources in transition-metal catalyzed transfer hydrogenation systems. This chapter highlights effective transfer hydrogenation and asymmetric transfer hydrogenation of ketones catalyzed by transition-metal complexes. The reactions described in this section are classified according to the reducing agents employed and the type of ketone substrate.

Key words

transfer hydrogenation - asymmetric transfer hydrogenation - ketones - esters - alcohols - propan-2-ol - formic acid - formate salts - metal-ligand cooperation - dynamic kinetic resolution - reduction

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