de Vries, J. G.: 2018 Science of Synthesis, 2017/6: Catalytic Reduction in Organic Synthesis 2 DOI: 10.1055/sos-SD-227-00014
Catalytic Reduction in Organic Synthesis 2

2.2 Transfer Hydrogenation of Ketones to Alcohols

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Book

Editor: de Vries, J. G.

Authors: Ayad, T.; Bagal, D. B.; Besson, M.; Bhanage, B. M.; Ciszek, B.; Claver, C.; Cole-Hamilton, D. J.; Fleischer, I.; Hinze, S.; Ikariya, T.; Junge, K.; Kalck, P.; Kamer, P. C. J.; Kayaki, Y.; Llopis, Q.; Matsunami, A.; Monguchi, Y.; Peñafiel, I.; Phansavath, P.; Pinel, C.; Puylaert, P.; Ratovelomanana-Vidal, V.; Sajiki, H.; Savini, A.; Shi, Y.; Steinfeldt, N.; Urrutigoïty, M.

Title: Catalytic Reduction in Organic Synthesis 2

Print ISBN: 9783132406261; Online ISBN: 9783132406308; Book DOI: 10.1055/b-005-145235

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

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Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Koch, G.; Molander, G. A.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.

Type: Multivolume Edition

 


A. Matsunami; Y. Kayaki; T. Ikariya

Abstract

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Transfer hydrogenation offers an alternative to hydrogenation using gaseous hydrogen, as well as a practical synthetic approach to enantiopure compounds. Alcohols, formic acid, and formate salts are often used as safe and nontoxic hydrogen sources in transition-metal catalyzed transfer hydrogenation systems. This chapter highlights effective transfer hydrogenation and asymmetric transfer hydrogenation of ketones catalyzed by transition-metal complexes. The reactions described in this section are classified according to the reducing agents employed and the type of ketone substrate.

 
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