3 Separation and Purification in the Continuous Synthesis of Fine Chemicals and Pharmaceuticals

M. O’Mahony; S. Ferguson; T. Stelzer; A. Myerson

Abstract

Of use to both chemists and chemical engineers working in flow synthesis, this chapter provides a summary of separation and purification operations that can be applied to flow synthesis reaction streams. Both single and biphasic separations for the liquid phase are detailed. Separation and purification by continuous crystallization of a solid phase is covered. Continuous solid–liquid separation and drying technologies for the isolation of a fine-chemical or pharmaceutical product are also reviewed.

Schlüsselwörter

flow chemistry - continuous separation - pharmaceuticals - nanofiltration - membrane extractors - continuous crystallization - integrated continuous manufacturing - continuous solid–liquid separation - filtration - continuous filtration - continuous isolation and drying

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