11 Immobilized Catalysts for Asymmetric Reactions
Book
Editors: Jamison, T. F.; Koch, G.
Title: Flow Chemistry in Organic Synthesis
Print ISBN: 9783132423312; Online ISBN: 9783132423350; Book DOI: 10.1055/b-006-161272
1st edition © 2018. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner (Editor-in-Chief), A.; Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract
Recent applications of polymer-immobilized catalysts for asymmetric reactions are described in this chapter. The chiral catalysts covered include organocatalysts, Lewis acid catalysts, and transition-metal catalysts. Preparation of these chiral polymer-immobilized catalysts and their use in asymmetric reactions are described. The polymer-immobilized catalysts are insoluble in the solvent used for asymmetric reactions and are easily separated from the reaction mixture; the recovered polymeric catalysts can be reused many times without any loss of the catalytic performance. Some of these polymeric catalysts have been used in continuous-flow systems, potentially providing a powerful tool for the synthesis of optically active fine chemicals.
Key words
Keywords: - polymer-immobilized catalysts - organocatalysts - cinchona alkaloids - Lewis acid catalysts - transition-metal catalysts - asymmetric reactions - flow chemistry- 7 Cinchona Alkaloids in Synthesis and Catalysis: Ligands, Immobilization and Organocatalysis. Song CE. Wiley-VCH; Weinheim, Germany 2009
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