PDF herunterladen
Jamison, T. F. et al.: 2018 Science of Synthesis, 2018/5: Flow Chemistry in Organic Synthesis DOI: 10.1055/sos-SD-228-00247
Flow Chemistry in Organic Synthesis

15.1 Flow Chemistry in the Pharmaceutical Industry: Part 1

Weitere Informationen

Buch

Herausgeber: Jamison, T. F.; Koch, G.

Autoren: Beeler, A. B.; Beingessner, R. L.; Bottecchia, C.; Browne, D. L.; Coley, C. W.; Ferguson, S.; Folgueiras-Amador, A. A.; Gilmore, K.; Hicklin, R. W.; Imbrogno, J.; Itsuno, S.; Jamison, T. F.; Jensen, K. F.; Kelly, L. P.; Kerr, M. S.; Kiesman, W. F.; Kim, H.; Kwok, D.-I. A.; Ley, S. V.; Longstreet, A. R.; May, S. A.; McTeague, T. A.; Mijalis, A. J.; Mo, Y.; Moon, S.; Myerson, A.; Noël, T.; O’Brien, A. G.; O’Brien, M.; O’Mahony, M.; Opalka, S. M.; Pentelute, B. L.; Polyzos, A.; Schepartz, A.; Seeberger, P. H.; Seo, H.; Steinauer, A.; Stelzer, T.; Stephenson, C. R. J.; Strom, A. E.; Styduhar, E. D.; Sun, A. C.; Telmesani, R.; Thomas, D. A.; Tran, T. H.; Ullah, M. S.; Wicker, A. C.; Wirth, T.; Yoshida, J.

Titel: Flow Chemistry in Organic Synthesis

Print ISBN: 9783132423312; Online ISBN: 9783132423350; Buch-DOI: 10.1055/b-006-161272

1st edition © 2018. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie

Science of Synthesis Reference Libraries



Übergeordnete Publikation

Titel: Science of Synthesis

DOI: 10.1055/b-00000101

Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Typ: Mehrbändiges Werk

Auch verfügbar auf
 


Abstract

The use of flow chemistry in the single- and multistep synthesis of active pharmaceutical ingredients has been well demonstrated. The pharmaceutical industry is now taking the next steps towards integration of flow chemistry into large-scale commercialized processes, which can effectively supply patient populations. This chapter details advances in this area, and outlines the data and knowledge required to select, develop, scale, and commercialize an efficient flow process.

Schlüsselwörter

continuous-flow processes - pharmaceuticals - multistep processes - process selection - process development - scaleup - process optimization
 
  • 4 Cole KP, McClary Groh J, Johnson MD, Burcham CL, Campbell BM, Diseroad WD, Heller MR, Howell JR, Kallman NJ, Koenig TM, May SA, Miller RD, Mitchell D, Myers DP, Myers SS, Phillips JL, Polster CS, White TD, Cashman J, Hurley D, Moylan R, Sheehan P, Spencer RD, Desmond K, Desmond P, Gowran O. Science (Washington, D. C.) 2017; 356: 1144
    CrossrefPubMedSuche in Google Scholar
  • 5 Adamo A, Beingessner RL, Behnam M, Chen J, Jamison TF, Jensen KF, Manbaliu J.-CM, Myerson AS, Revalor EM, Snead DR, Stelzer T, Weeranoppanant N, Wong SY, Zhang P. Science (Washington, D. C.) 2016; 352: 61
    CrossrefPubMedSuche in Google Scholar
  • 7 Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing, am EndeDJ, Ed.; Wiley: Hoboken, NJ, (2010).
  • 30 Guidance for Industry: PAT – A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance; available online at https://www.fda.gov/downloads/drugs/guidances/ucm070 305.pdf (accessed November 6, 2017).
  • 35 Nauman EB, In: Handbook of Industrial Mixing: Science and Practice Paul EL, Atiemo-Obeng VA, Kresta SM. Wiley Hoboken, NJ 2004; 1-18
  • 42 Allison G, Cain YT, Cooney C, Garcia T, Gooen Bizjak T, Holte O, Jagota N, Komas B, Korakianiti E, Kourti D, Madurawe R, Morefield E, Montgomery F, Nasr M, Randolph W, Robert J.-L, Rudd D, Zezza D. J. Pharm. Sci. 2015; 104: 803
    CrossrefPubMedSuche in Google Scholar
  • 43 Nasr MM, Krumme M, Matsuda Y, Trout BL, Badman C, Mascia S, Cooney CL, Jensen KD, Florence A, Johnston C, Konstantinov K, Lee SL. J. Pharm. Sci. 2017; 106: 3199
    CrossrefPubMedSuche in Google Scholar