Download PDF
Jamison, T. F. et al.: 2018 Science of Synthesis, 2018/5: Flow Chemistry in Organic Synthesis DOI: 10.1055/sos-SD-228-00262
Flow Chemistry in Organic Synthesis

15.3 Flow Chemistry in the Pharmaceutical Industry: Part 3

More Information

Book

Editors: Jamison, T. F.; Koch, G.

Authors: Beeler, A. B.; Beingessner, R. L.; Bottecchia, C.; Browne, D. L.; Coley, C. W.; Ferguson, S.; Folgueiras-Amador, A. A.; Gilmore, K.; Hicklin, R. W.; Imbrogno, J.; Itsuno, S.; Jamison, T. F.; Jensen, K. F.; Kelly, L. P.; Kerr, M. S.; Kiesman, W. F.; Kim, H.; Kwok, D.-I. A.; Ley, S. V.; Longstreet, A. R.; May, S. A.; McTeague, T. A.; Mijalis, A. J.; Mo, Y.; Moon, S.; Myerson, A.; Noël, T.; O’Brien, A. G.; O’Brien, M.; O’Mahony, M.; Opalka, S. M.; Pentelute, B. L.; Polyzos, A.; Schepartz, A.; Seeberger, P. H.; Seo, H.; Steinauer, A.; Stelzer, T.; Stephenson, C. R. J.; Strom, A. E.; Styduhar, E. D.; Sun, A. C.; Telmesani, R.; Thomas, D. A.; Tran, T. H.; Ullah, M. S.; Wicker, A. C.; Wirth, T.; Yoshida, J.

Title: Flow Chemistry in Organic Synthesis

Print ISBN: 9783132423312; Online ISBN: 9783132423350; Book DOI: 10.1055/b-006-161272

1st edition © 2018. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

Also available at
 


Abstract

When considering whether to develop a flow-chemistry approach to a particular synthetic route, the criteria of safety, quality, cost, sustainability, scalability, and speed are all considered. This chapter presents a case study of a single reaction, the formylation of an aryl bromide, being performed in a batch reactor, a microreactor, a plug-flow reactor, and a spinning-disk reactor. An assessment of the various technologies is made with respect to the abovementioned criteria.

Key words

flow chemistry - scale-up - batch reactions - microreactors - plug-flow reactors - spinning-disk reactors - process development - optimization
 
  • 7 Kopach ME, Cole KP, Pollock PM, Johnson MD, Braden TM, Webster LP, McClary Groh J, McFarland AD, Schafer JP, Adler JJ, Rosemeyer M. Org. Process Res. Dev. 2016; 20: 1581
    CrossrefSearch in Google Scholar
  • 9 Throughout this chapter, the terms butyllithium and BuLi refer to the unbranched alkyllithium, n-butyllithium.
  • 21 Roberge D, Rainone F, Quittmann W, Gottsponer M, Eyholzer M. WO 2011023761, 2011
    PubMed
  • 25 Boodhoo K, In: Process Intensification for Green Chemistry: Engineering Solutions for Sustainable Chemical Processing Boodhoo K, Harvey A. Wiley Hoboken, NJ 2013; 59-90
    Crossref
  • 27 A newer model can now operate at pressures of up to 10 bar.
  • 32 Poechlauer P, Colberg J, Fisher E, Jansen M, Johnson MD, Koenig SG, Lawler M, Laporte T, Manley J, Martin B, OʼKearney-McMullan A. Org. Process Res. Dev. 2013; 17: 1472
    CrossrefSearch in Google Scholar
  • 36 May SA, Johnson MD, Braden TM, Calvin JR, Haeberle BD, Jines AR, Miller RD, Plocharczyk EF, Rener GA, Richey RN, Schmid CR, Vaid RK, Yu H. Org. Process Res. Dev. 2012; 16: 982
    CrossrefSearch in Google Scholar
  • 39 Hohmann L, Löbnitz L, Menke C, Santhirakumaran B, Stier P, Stenger F, Dufour F, Wiese G, zur Horst-Meyer S, Kusserow B, Zang W, Nirschl H, Kockmann N. Chem. Eng. Technol. 2018; 41: 1152
    CrossrefSearch in Google Scholar
  • 40 Cole KP, McClary Groh J, Johnson MD, Burcham CL, Campbell BM, Diseroad WD, Heller MR, Howell JR, Kallman NJ, Koenig TM, May SA, Miller RD, Mitchell D, Myers DP, Myers SS, Phillips JL, Polster CS, White TD, Cashman J, Hurley D, Moylan R, Sheehan P, Spencer RD, Desmond K, Desmond P, Gowran O. Science (Washington, D. C.) 2017; 356: 1144
    CrossrefPubMedSearch in Google Scholar