15.3 Flow Chemistry in the Pharmaceutical Industry: Part 3

S. M. Opalka; W. F. Kiesman; D.-I. A. Kwok

Abstract

When considering whether to develop a flow-chemistry approach to a particular synthetic route, the criteria of safety, quality, cost, sustainability, scalability, and speed are all considered. This chapter presents a case study of a single reaction, the formylation of an aryl bromide, being performed in a batch reactor, a microreactor, a plug-flow reactor, and a spinning-disk reactor. An assessment of the various technologies is made with respect to the abovementioned criteria.

Schlüsselwörter

flow chemistry - scale-up - batch reactions - microreactors - plug-flow reactors - spinning-disk reactors - process development - optimization

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