2.12 Asymmetric Catalysis of Radical Reactions

Abstract

Synthetic methodologies based on radical chemistry are efficient and powerful tools for the construction of carbon–carbon and carbon–heteroatom bonds. This chapter highlights the significance of asymmetric catalysis in free-radical reactions. Several asymmetric catalytic principles, ranging from early chiral Lewis acid and organocatalytic activation to recent photoredox and transition-metal-based asymmetric catalytic systems, are discussed.

Key words

asymmetric catalysis - radical reactions - chiral Lewis acids - hydrogen-atom transfer - chiral aluminum Lewis acids - chiral Brønsted acids - organocatalysis - photoredox catalysis - transition-metal catalysis - single-electron transfer - chiral porphyrins - chiral N-heterocyclic carbenes

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