1.14 Nickel-Catalyzed Directed C—H Functionalization

Abstract

This chapter summarizes some selected examples of nickel-catalyzed directed C—H functionalization reactions that involve the activation of a C—H bond as a key step. It is now recognized that nickel complexes, mostly nickel(0) and nickel(II), are some of the most attractive and effective catalysts for the development of C—H functionalization reactions because of the low cost and earth-abundance of nickel, and, most importantly, because the complexes can exist in various oxidation states (+1, +2, +3, and +4) during the transformation, which leads to unique reactivity.

Key words

nickel catalysis - C—H activation - C—H alkylation - C—H alkynylation - C—H amination - C—H annulation - C—H arylation - C—H functionalization - directing groups

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