2.9 Iron-Catalyzed Cross Coupling of Aryl and Vinyl Electrophiles

Abstract

This review focuses on cross-coupling methodologies that utilize aryl and vinyl electrophiles relying on iron-based catalysts. We have outlined the most relevant and better-established methodologies; leading to the discussion of significant cases based on hard nucleophiles, with the number of examples dropping with their increasing softness. In addition, we describe several useful transformations based on reactive unsaturated nucleophiles, such as acetylenes and alkenes.

Key words

iron catalysis - aryl electrophiles - vinyl electrophiles - C—C bond formation - first-row transition-metal catalysis - iron-catalyzed Kumada-type reaction - iron-catalyzed Sonogashira reaction - iron-catalyzed Mizoroki–Heck reaction - iron-catalyzed Negishi reaction - substrate-directed iron-catalyzed Suzuki cross coupling

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