2.8 Iron-Catalyzed C—H Functionalization
Buch
Herausgeber: Yoshikai, N.
Titel: Base-Metal Catalysis 2
Print ISBN: 9783132455030; Online ISBN: 9783132455054; Buch-DOI: 10.1055/b000000440
1st edition © 2023 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Typ: Mehrbändiges Werk
Abstract
The direct functionalization of an organic substrate via transition-metal-catalyzed C—H bond activation is a powerful tool for building molecular complexity. Despite the abundance, low cost, and low toxicity of iron, which make it an ideal metal for sustainable catalysis, iron-catalyzed C—H activation has been less investigated compared with catalysis based on precious metals such as palladium or iridium. In this chapter, selected examples of iron-catalyzed activation of a C—H bond to create a new C—C bond are described. Arylation, hetarylation, alkenylation, and alkylation of C(sp2)—H and C(sp3)—H bonds is discussed. Most of the substrates require a directing group, but several examples of non-directed reactions are also presented. The functionalization of a C—H bond has been achieved by using organometallic reagents, organic halides and pseudohalides, multiple bonds such as alkenes and alkynes, and arenes or hetarenes as the reaction partner.
Schlüsselwörter
C—H activation - C—H functionalization - C—C bond formation - iron catalysis - arylation - alkenylation - alkylation - directing group - bipyridine ligands - phosphine ligands - NHC ligands - organometallic reagents - alkyl halides - alkenes - alkynes - arenes - hetarenes- 2 C-H Bond Activation and Catalytic Functionalization. Dixneuf PH, Doucet H. Springer; Berlin 2016. Topics in Organometallic Chemistry
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