2.17 Catalytic Nozaki–Hiyama–Kishi (NHK) Type Reactions
Book
Editor: Yoshikai, N.
Title: Base-Metal Catalysis 2
Print ISBN: 9783132455030; Online ISBN: 9783132455054; Book DOI: 10.1055/b000000440
1st edition © 2023 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract
![](https://www.thieme-connect.de/media/10.1055-b000000440/thumbnails/a_225yor.jpg)
The Nozaki–Hiyama–Kishi (NHK) reaction has been established to be an efficient and reliable means for carbon–carbon bond formation that has been proven in the synthesis of many complex molecules. However, the use of an equivalent of a reductant and the strict requirements in terms of the conditions have limited its wide application. The current research direction is to develop more readily available carbon radical precursors and complementary activation mechanisms; for example, the use of light (photocatalysis) and electricity have found preliminary success in realizing the catalytic cycle of chromium.
Key words
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