2.5 Cobalt-Catalyzed Bidentate-Chelation-Assisted C—H Functionalization

Abstract

C—H bond functionalization catalyzed by high-valent-cobalt species with the aid of bidentate chelation has come a long way since the pioneering report by Daugulis almost a decade ago. Further study of the reaction mechanisms revealed that stoichiometric amounts of metal salts could be replaced with photocatalysts or electricity as one-electron oxidants, and approaches based on these strategies can be considered more environmentally friendly than the initially developed catalytic systems. Systematic investigations have led to a better understanding of the coordination environment of the in-situ-formed cobaltacycle, and this has led to the development of external chiral ligands for cobalt-catalyzed asymmetric C—H functionalizations. This review is a comprehensive summary of the documented methods for cobalt-catalyzed, bidentate-chelation-assisted C—H bond functionalizations as of early 2023.

Key words

C—H activation - C—H functionalization - cobalt catalysis - directing groups - C(sp2)—H functionalization - C(sp3)—H functionalization - bidentate chelation - bidentate directing groups - enantioselective C—H functionalization - electrocatalysis - photoredox catalysis - asymmetric catalysis - sustainable catalysis

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