9 (Het)Arene/Alkane Cross-Dehydrogenative Coupling for C(sp²)—C(sp³) Bond Formation

Abstract

Introduction of alkyl groups onto arenes and hetarenes is a fundamental modification of (het)arenes and can exert significant effects on their physical, chemical, and/or biological properties. Among alkylation reactions, the cross-dehydrogenative coupling of (het)arenes with hydrocarbons through double C—H bond cleavage is a straightforward synthetic method that avoids prefunctionalization of the substrate(s). This review provides an overview of the alkylation of (het)arenes, including arenes, perfluoroarenes, and nitrogen, oxygen, and sulfur heterocycles, by hydrocarbons via cross-dehydrogenative coupling.

Key words

cross-dehydrogenative coupling - alkylation - arylation - catalysis - carbon–carbon bond formation - cross-coupling reactions - oxidation - arenes - pyridines - quinolines - indoles - pyrroles - benzimidazoles - benzothiazoles - nucleosides - coumarins - furans - thiophenes - benzothiophenes

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