9 (Het)Arene/Alkane Cross-Dehydrogenative Coupling for C(sp2)—C(sp3) Bond Formation
Book
Editor: Maiti, D.
Title: Cross-Dehydrogenative Coupling
Print ISBN: 9783132455245; Online ISBN: 9783132455269; Book DOI: 10.1055/b000000640
1st edition © 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract
![](https://www.thieme-connect.de/media/10.1055-b000000640/thumbnails/a_226dmi.jpg)
Introduction of alkyl groups onto arenes and hetarenes is a fundamental modification of (het)arenes and can exert significant effects on their physical, chemical, and/or biological properties. Among alkylation reactions, the cross-dehydrogenative coupling of (het)arenes with hydrocarbons through double C—H bond cleavage is a straightforward synthetic method that avoids prefunctionalization of the substrate(s). This review provides an overview of the alkylation of (het)arenes, including arenes, perfluoroarenes, and nitrogen, oxygen, and sulfur heterocycles, by hydrocarbons via cross-dehydrogenative coupling.
Key words
cross-dehydrogenative coupling - alkylation - arylation - catalysis - carbon–carbon bond formation - cross-coupling reactions - oxidation - arenes - pyridines - quinolines - indoles - pyrroles - benzimidazoles - benzothiazoles - nucleosides - coumarins - furans - thiophenes - benzothiophenes- 5 Varun BV, Dhineshkumar J, Bettadapur KR, Siddaraju Y, Alagiri K, Prabhu KR. Tetrahedron Lett. 2017; 58: 803
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