8 Cross-Dehydrogenative Coupling Involving Aldehydes for C(sp²)—C(sp²) Bond Formation

Abstract

Aldehydes have been widely utilized as an acyl source for the construction of C(sp²)—C(sp²) bonds via cross-dehydrogenative coupling (CDC) in an efficient and sustainable strategy. The aldehyde-based acylation is an important methodology for the synthesis of diaryl ketones, a significant motif in the field of agrochemicals, pharmaceuticals, and dyes. The process of C(sp²)—C(sp²) bond construction is accomplished under metal-free, transition-metal-mediated, or photochemical conditions. During the process, the oxidant alone, or in combination with transition metals, plays a crucial role. In this chapter, we have highlighted the advances made in this field, along with published reports and procedures.

Key words

cross-dehydrogenative coupling - acyl sources - aldehydes - diaryl ketones - C(sp2)—C(sp2) bond formation - photocatalysis - transition-metal catalysis - metal-free

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