2.7 On-DNA Cyclization Reactions
Buch
Herausgeber: Scheuermann, J. ; Li, Y.
Titel: DNA-Encoded Libraries
Print ISBN: 9783132455221; Online ISBN: 9783132437357; Buch-DOI: 10.1055/b000000342
1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Typ: Mehrbändiges Werk
Abstract
On-DNA cyclization has proven to be a successful strategy, and demonstrates significant advantages for introducing structural diversity of ring systems as core structures that are present in the majority of bioactive molecules such as FDA-approved drugs, agrochemicals, and natural products. On-DNA cyclization reactions provide an attractive avenue to build highly diverse DELs based on ring systems with appropriate functionalization. In this review, synthetic strategies to access ring systems such as five-membered rings, six-membered rings, spiro rings, fused rings, and bridged rings, using on-DNA cyclization protocols, are collated.
Schlüsselwörter
DNA-encoded libraries - DNA-compatible reactions - cyclizations - ring systems - heterocycles-
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