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Scheuermann, J.  et al.: 2024 Science of Synthesis, 2023/5: DNA-Encoded Libraries DOI: 10.1055/sos-SD-241-00276
DNA-Encoded Libraries

3.2.2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries

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Book

Editors: Scheuermann, J. ; Li, Y. 

Authors: Barluenga, S. ; Bassi, G. ; Brunschweiger, A. ; Cai, B. ; Cazzamalli, S. ; Chheda, P. ; Cui, M. ; Cui, W. ; Fang, X. ; Farrera-Soler, L. ; Favalli, N. ; Feng, J.; Foley, T. L. ; Franzini, R. M. ; Georgiev, T. ; Gillingham, D. ; Gloger, A. ; Graham, J. D. ; Granados, A. ; Heiden, S.; Hou, W. ; Huang, Y. ; Keefe, A. D. ; Krusemark, C. J. ; Li, X. ; Li, Y. ; Lin, W. ; Litovchick, A.; Liu, G. ; Lu, X. ; Lucaroni, L. ; Ma, P. ; Migliorini, F. ; Molander, G. A. ; Neri, D. ; Nie, Q. ; Oehler, S. ; Prati, L. ; Puglioli, S. ; Reddavide, F. V. ; Satz, A. L. ; Sauter, B. ; Scheuermann, J. ; Schuman, D.; Simmons, N. ; Stanway-Gordon, H. A. ; Su, W. ; Sun, J. ; Thompson, M.; Vummidi, B. R.; Wang, X. ; Wang, Y. ; Wang, Z. ; Waring, M. J. ; Willems, S.; Winssinger, N. ; Xia, B. ; Xiong, F. ; Xu, H. ; Xu, L. ; Yang, G. ; Zhang, G. ; Zhang, Y. ; Zhou, Y. 

Title: DNA-Encoded Libraries

Print ISBN: 9783132455221; Online ISBN: 9783132437357; Book DOI: 10.1055/b000000342

1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

Also available at
 


Abstract

DNA-encoded dynamic combinatorial chemical library (EDCCL) technology is the application of dynamic combinatorial chemistry (DCC) in the field of DNA-encoded library (DEL) technology. EDCCL technology can be used for de novo selection as well as to convert lead compounds into high-affinity bivalent binders. EDCCL technology aims to combine the advantages of DCC and DEL, while addressing some drawbacks from both.

Key words

DNA-encoded libraries - dynamic combinatorial chemistry (DCC) - fragment-based drug discovery - chelate effect - dual pharmacophores
 
  • 1 Corbett PT, Leclaire J, Vial L, West KR, Wietor J.-L, Sanders JKM, Otto S. Chem. Rev. 2006; 106: 3652
  • 2 Mondal M, Hirsch AKH. Chem. Soc. Rev. 2015; 44: 2455
  • 3 Ramström O, Lehn J.-M. Nat. Rev. Drug Discovery 2002; 1: 26
  • 4 Frei P, Hevey R, Ernst B. Chem.–Eur. J. 2019; 25: 60
  • 5 Nasr G, Petit E, Supuran CT, Winum J.-Y, Barboiu M. Bioorg. Med. Chem. Lett. 2009; 19: 6014
  • 6 Mocharla VP, Colasson B, Lee LV, Röper S, Sharpless KB, Wong C.-H, Kolb HC. Angew. Chem. Int. Ed. 2005; 44: 116
  • 7 Mondal M, Unver MY, Pal A, Bakker M, Berrier SP, Hirsch AKH. Chem.–Eur. J. 2016; 22: 14826
  • 8 Hartman AM, Gierse RM, Hirsch AKH. Eur. J. Org. Chem. 2019; 3581
  • 9 Buller F, Steiner M, Scheuermann J, Mannocci L, Nissen I, Kohler M, Beisel C, Neri D. Bioorg. Med. Chem. Lett. 2010; 20: 4188
  • 10 Herrmann A. Chem. Soc. Rev. 2014; 43: 1899
  • 11 Huang R, Leung I. Molecules 2016; 21: 910
  • 12 Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, Lakdawala AS, Lehr R, McNulty DE, Nagilla R, Ouellette MT, Pao CS, Rendina AR, Schaeffer MC, Summerfield JD, Swift BA, Totoritis RD, Ward P, Zhang A, Zhang D, Marquis RW, Bertin J, Gough PJ. J. Med. Chem. 2016; 59: 2163
  • 13 Fernández-Montalván AE, Berger M, Kuropka B, Koo SJ, Badock V, Weiske J, Puetter V, Holton SJ, Stöckigt D, ter Laak A, Centrella PA, Clark MA, Dumelin CE, Sigel EA, Soutter HH, Troast DM, Zhang Y, Cuozzo JW, Keefe AD, Roche D, Rodeschini V, Chaikuad A, Díaz-Sáez L, Bennett JM, Fedorov O, Huber KVM, Hübner J, Weinmann H, Hartung IV, Gorjánácz M. ACS Chem. Biol. 2017; 12: 2730
  • 14 Clark MA, Acharya RA, Arico-Muendel CC, Belyanskaya SL, Benjamin DR, Carlson NR, Centrella PA, Chiu CH, Creaser SP, Cuozzo JW, Davie CP, Ding Y, Franklin GJ, Franzen KD, Gefter ML, Hale SP, Hansen NJV, Israel DI, Jiang J, Kavarana MJ, Kelley MS, Kollmann CS, Li F, Lind K, Mataruse S, Medeiros PF, Messer JA, Myers P, OʼKeefe H, Oliff MC, Rise CE, Satz AL, Skinner SR, Svendsen JL, Tang L, van Vloten K, Wagner RW, Yao G, Zhao B, Morgan BA. Nat. Chem. Biol. 2009; 5: 647
  • 15 Kunig VBK, Potowski M, Klika Škopić M, Brunschweiger A. ChemMedChem 2021; 16: 1048
  • 16 Melkko S, Scheuermann J, Dumelin CE, Neri D. Nat. Biotechnol. 2004; 22: 568
  • 17 Melkko S, Zhang Y, Dumelin CE, Scheuermann J, Neri D. Angew. Chem. Int. Ed. 2007; 46: 4671
  • 18 Wichert M, Krall N, Decurtins W, Franzini RM, Pretto F, Schneider P, Neri D, Scheuermann J. Nat. Chem. 2015; 7: 241
  • 19 Reddavide FV, Lin W, Lehnert S, Zhang Y. Angew. Chem. Int. Ed. 2015; 54: 7924
  • 20 Li G, Zheng W, Chen Z, Zhou Y, Liu Y, Yang J, Huang Y, Li X. Chem. Sci. 2015; 6: 7097
  • 21 Reddavide FV, Cui M, Lin W, Fu N, Heiden S, Andrade H, Thompson M, Zhang Y. Chem. Commun. (Cambridge) 2019; 55: 3753
  • 22 Zhou Y, Li C, Peng J, Xie L, Meng L, Li Q, Zhang J, Li XD, Li X, Huang X, Li X. J. Am. Chem. Soc. 2018; 140: 15859
  • 23 Lee JB, Shai AS, Campolongo MJ, Park N, Luo D. ChemPhysChem 2010; 11: 2081
  • 24 Chatterjee S, Lee JB, Valappil NV, Luo D, Menon VM. Nanoscale 2012; 4: 1568
  • 25 Hartman MR, Yang D, Tran TNN, Lee K, Kahn JS, Kiatwuthinon P, Yancey KG, Trotsenko O, Minko S, Luo D. Angew. Chem. Int. Ed. 2013; 52: 8699
  • 26 Sprinz KI, Tagore DM, Hamilton AD. Bioorg. Med. Chem. Lett. 2005; 15: 3908
  • 27 Grünzner S, Reddavide FV, Steinfelder C, Cui M, Busek M, Klotzbach U, Zhang Y, Sonntag F, Gray BL, Becker H. 10061 Microfluidics, BioMEMS, and Medical Microsystems XV 2017; 1006 111