3.2.2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries

Abstract

DNA-encoded dynamic combinatorial chemical library (EDCCL) technology is the application of dynamic combinatorial chemistry (DCC) in the field of DNA-encoded library (DEL) technology. EDCCL technology can be used for de novo selection as well as to convert lead compounds into high-affinity bivalent binders. EDCCL technology aims to combine the advantages of DCC and DEL, while addressing some drawbacks from both.

Schlüsselwörter

DNA-encoded libraries - dynamic combinatorial chemistry (DCC) - fragment-based drug discovery - chelate effect - dual pharmacophores

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