14 Bioorthogonal Strategies for the Uncaging and Assembly of Drugs
Book
Editors: Mascareñas, J. L.; Tomás-Gamasa, M.
Title: Abiotic Reactions in Live Environments
Online ISBN: 9783132458277; Book DOI: 10.1055/b000000918
early view © Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Laboratory Techniques, Stoichiometry;Biochemistry;Pharmaceutical Chemistry, Medizinische Chemie
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract
The bioorthogonal synthesis of drugs offers a unique opportunity for targeting — either molecularly, spatiotemporally or both — the delivery of active compounds directly to the disease site. Problems such as unfavorable pharmacokinetic (PK) profiles and dose-limiting side effects can be mitigated with the careful deployment of the tools of biorthogonal chemistry. In order to access medicinal applications, researchers have developed groundbreaking new chemistries for the caging and uncaging, assembly, and molecular targeting of a wide range of clinically approved drugs. This review presents notable examples of bioorthogonal drug synthesis that have emerged from the two main branches of the bioorthogonal field: organic click chemistries and transition-metal-catalyzed reactions.
Key words
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