Abstract
The authors set out to investigate the inflammatory response and its impact on the hemodynamic function in stable and unstable coronary artery bypass (CABG) patients. Nineteen stable and twenty unstable patients were included in this prospective study. Serum IL-6, IL-8, TNF-α, and IL-10 were measured before, during and after cardiopulmonary bypass (CPB). Hemodynamic data was also collected. TNF-α was detected more often in unstable patients than in stable patients before (p = 0.03) and after CPB (p<0.01). TNF-α response after CPB was evident (p = 0.03). Serum IL-6 and IL-8 level were significantly increased after 10 minutes of CPB, reaching the peak value at 6 hours after declamping. IL-10 level reached the highest, 6.8 × the baseline at 6 hours after declamping in the unstable, but 3.3 × of baseline on the first post-operative day (POD) in the stable patients (p = 0.04). CI was better preserved in unstable patients (p = 0.04). Serum TNF-α was more likely to be found in patients with recent unstable episodes. CPB induces a release of serum IL-6, IL-8 and IL-10. Recent unstable angina seems to modify the cytokine response and hemodynamic outcome.
