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Int J Angiol 1997; 6(2): 89-90
DOI: 10.1007/BF01616675
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

Leukotriene production is increased in lower limb ischemia

Perttu Rossi1 , Pekka Kuukasjärvi1 , Juha-Pekka Salenius1 , Matti Tarkka1 , Juha Alanko2
  • 1Department of Surgery, Tampere University Hospital, Tampere, Finland
  • 2School of Medicine, University Of Tampere, Tampere, Finland
Presented at The 37th Annual World Congress, International College of Angiology, Helsinki, Finland, July 1995
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Publikationsdatum:
23. April 2011 (online)

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Abstract

Leukotrienes, derived from arachidonic acid by the 5-lipoxygenase pathway, have been implicated in unstable angina and in acute myocardial infarction. The aim of the present study was to investigate if leukotriene production is increased in acute and chronic lower limb ischemia. Leukotriene E4 excretion was increased in both acute (152 ± 38 pg/mg creatinine, mean ± SEM, n=11, p < 0.001) and chronic (140 ± 45 pg/mg creatinine, n=8, p < 0.001) lower limb ischemia about 7-fold compared with healthy volunteers (22 ± 3 pg/mg creatinine, n = 17). Leukotriene synthesis seems to be increased because of insufficience of blood flow and microcirculation or acute tissue injury. We propose that increased leukotriene synthesis in lower limb ischemia reflects leukocyte activation.