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Int J Angiol 1997; 6(2): 110-114
DOI: 10.1007/BF01616679
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

Endothelium-derived factors of veins: Implications in development of venous disease

Virginia M. Miller
  • Departments of Surgery and Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Presented at the 37th Annual World Congress, International College of Angiology, Helsinki, Finland as part of the Workshop “Venous Disease from Basic Science to Clinical Practice, July 1995.”
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Publication History

Publication Date:
23 April 2011 (online)

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Abstract

Vascular endothelia release paracrine factors which affect aggregation of platelets and the tone and proliferation of the underlying smooth muscle. These endothelium-derived factors are released in response to two limbs of Virchow's triad: (1) substances associated with the coagulation cascade, and (2) changes in blood flow. Therefore, dysfunction of the venous endothelium could contribute to development of deep venous thrombosis and structural disease of the venous wall.