Absence of ANCA in Behçet's syndrome with large vessel involvement

Recep Tunc; Fatma Ozbakir; Aygul Caglayan; M. Riza Altiparmak; Pelin Yargan; Izzet Fresko; Hasan Yazici

doi:10.1007/BF01637045

International Journal of Angiology, Table of Contents

Int J Angiol 2001; 10(4): 260-262
DOI: 10.1007/BF01637045

Original Articles

Absence of ANCA in Behçet's syndrome with large vessel involvement

Recep Tunc¹ , Fatma Ozbakir¹ , Aygul Caglayan² , M. Riza Altiparmak² , Pelin Yargan² , Izzet Fresko² , Hasan Yazici²

¹Department of Internal Medicine, Faculty of Medicine, Selcuk University, Konya
²Behçet's Syndrome Research Center Department of Rheumatology, Cerrahpasa Medical Faculty, Istanbul, Turkey

Abstract

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Abstract

The aim of this study was to examine the prevalence of anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Behcet's syndrome (BS) with large vessel involvement. The sera of 48 consecutive patients with BS with large vessel involvement, seven patients with Wegener granulomatosis (WG), and 10 healthy staff were studied for the presence of the cytoplasmic (c) and perinuclear (p) pattern of ANCA by indirect immunofluoresance (IIF). The sera were also examined for antibodies against proteinase 3 (anti-PR3) and myeloperoxidase (anti-MPO) by enzymelinked immunosorbent assay (ELISA). None of the sera from the patients with BS and healthy controls had detectable ANCAs, while all positive control sera from patients with WG showed ANCA positivity in some form. This study confirms that there are no detectable ANCAs in patients with BS with large vessel involvement by IIF and ELISA tests.

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